- 2-(4-Fluorophenyl)-thiophene
-
- $5.00 / 1KG
-
2024-04-16
- CAS:58861-48-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
|
| | 2-(4-Fluorophenyl)-thiophene Basic information |
| Product Name: | 2-(4-Fluorophenyl)-thiophene | | Synonyms: | IFLAB-BB F2108-0130;2-(4-FLUOROPHENYL)THIOPHENE;AKOS BAR-1344;Thiophene, 2-(4-fluorophenyl)-;Canagliflozin Intermediate I;Canagliflozin INT2;2-(4-fluorophenyl)thiophen;Canagliflozin Related Impurity 14 | | CAS: | 58861-48-6 | | MF: | C10H7FS | | MW: | 178.23 | | EINECS: | 611-756-1 | | Product Categories: | 58861-48-6 | | Mol File: | 58861-48-6.mol |  |
| | 2-(4-Fluorophenyl)-thiophene Chemical Properties |
| Melting point | 51.0 to 55.0 °C | | Boiling point | 252.3±15.0 °C(Predicted) | | density | 1.200±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | soluble in Methanol | | form | powder to crystal | | color | Light orange to Yellow to Green | | InChI | InChI=1S/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H | | InChIKey | PURJRGMZIKXDMW-UHFFFAOYSA-N | | SMILES | C1(C2=CC=C(F)C=C2)SC=CC=1 | | CAS DataBase Reference | 58861-48-6 |
| | 2-(4-Fluorophenyl)-thiophene Usage And Synthesis |
| Chemical Properties | white solid | | Uses | 2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus. | | Synthesis | 4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene. |
| | 2-(4-Fluorophenyl)-thiophene Preparation Products And Raw materials |
|