1227301-51-0
| 中文名称 | 1227301-51-0 |
|---|---|
| 中文同义词 | 化合物 T16524;化合物PHILANTHOTOXIN 74 盐酸盐;PHILANTHOTOXIN 74二盐酸盐 |
| 英文名称 | Philanthotoxin 74 |
| 英文同义词 | Philanthotoxin 74 (hydrochloride);Philanthotoxin 74 dihydrochloride;PhTx 74。2HCl;Benzenepropanamide, N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]-, hydrochloride (1:2), (αS)-;PhTx-74 dihydrochloride;PhTx-74 diHCl;(S)-N-(1-((7-((4-Aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide dihydrochloride |
| CAS号 | 1227301-51-0 |
| 分子式 | C24H43ClN4O3 |
| 分子量 | 471.08 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1227301-51-0.mol |
| 结构式 |  |
1227301-51-0 性质
| 储存条件 | Inert atmosphere,Room Temperature |
|---|---|
| 溶解度 | DMSO : 100 mg/mL (197.03 mM; 需要超声波)H2O : 50 mg/mL (98.51 mM; 需要超声波) |
| 形态 | 粉末 |
IC50: 296 nM (GluR1), 296 nM (GluR1)
Ki: 0.29 μM (GluR5Q)
Philanthotoxin 74 in the micromolar concentration range displays selective inhibition between the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 is reported to fully inhibit GluA1/A2R receptors when applied at a concentration of 500 μM while producing 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74, when tested at concentrations of 100 and 500 μM, displays pronounced channel block (more than 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Oocytes expressing GluA2R alone that homomeric GluA2R is virtually inert to philanthotoxin 74 in the 0.1-300 μM concentration range, displaying less than 5% inhibition at the maximum tested concentration of 300 μM. Philanthotoxin 74 inhibits these receptors nonselectively, with IC 50 values of about 30 μM, in both the presence and absence of γ-2.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-104020A | 1227301-51-0 Philanthotoxin 74 dihydrochloride | 1227301-51-0 | 1mg | 500元 |
| 2024/04/30 | HY-104020A | 1227301-51-0 Philanthotoxin 74 dihydrochloride | 1227301-51-0 | 5mg | 800元 |