- Z-PHG-OH
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- $0.00 / 1KG
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2026-04-24
- CAS:53990-33-3
- Min. Order: 10g
- Purity: 99%min
- Supply Ability: 10000G
- Z-Phg-OH
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- $50.00 / 1kg
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2025-05-23
- CAS:53990-33-3
- Min. Order: 1kg
- Purity: 99
- Supply Ability: 5000
- Z-PHG-OH
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- $15.00 / 1KG
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2021-08-12
- CAS:53990-33-3
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | Z-PHG-OH Basic information |
| Product Name: | Z-PHG-OH | | Synonyms: | N-ALPHA-CARBOBENZOXY-L-PHENYLGLYCINE;N-ALPHA-CBZ-L-PHENYLGLYCINE;N-CBZ-L-PHENYLGLYCINE;Z-(PHENYL)GLY-OH;Z-PHENYLGLYCINE;Z-L-PHENYLGLYCINE;Z-PHG-OH;CBZ-PHG-OH | | CAS: | 53990-33-3 | | MF: | C16H15NO4 | | MW: | 285.3 | | EINECS: | 1533716-785-6 | | Product Categories: | Phenylglycine [Phg] | | Mol File: | 53990-33-3.mol |  |
| | Z-PHG-OH Chemical Properties |
| Melting point | 131.0 to 135.0 °C | | Boiling point | 495.3±45.0 °C(Predicted) | | density | 1.275±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Ethanol (Slightly) | | form | Solid | | pka | 3.49±0.10(Predicted) | | color | White | | BRN | 4703006 | | Major Application | peptide synthesis | | InChI | InChI=1/C16H15NO4/c18-15(19)14(13-9-5-2-6-10-13)17-16(20)21-11-12-7-3-1-4-8-12/h1-10,14H,11H2,(H,17,20)(H,18,19)/t14-/s3 | | InChIKey | RLDJWBVOZVJJOS-WDHUHKLTNA-N | | SMILES | [C@H](C1C=CC=CC=1)(C(=O)O)NC(=O)OCC1C=CC=CC=1 |&1:0,r| | | CAS DataBase Reference | 53990-33-3(CAS DataBase Reference) |
| WGK Germany | 3 | | HS Code | 29242990 | | Storage Class | 11 - Combustible Solids |
| | Z-PHG-OH Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Uses | Z-L-Phenylglycine is an intermediate for the synthesis of Asimadoline Hydrochlorine (A788250), used in the treatment of IBS, a disorder associated with pain and altered bowel function. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | General procedure for the synthesis of the compound (CAS:5491-18-9) from L-phenylglycine and benzyl chloroformate: To an aqueous solution (500 mL) containing 2-amino-2-phenylacetic acid (20 g, 0.12 mol), sodium carbonate (27.97 g, 0.264 mol) and sodium bicarbonate (11.1 g, 0.132 mol) were added at room temperature. The mixture was stirred until a clarified solution was formed. Acetone (40 mL) was then added and the resulting slightly turbid solution was cooled to 15-20 °C in an ice water bath. Benzyl chloroformate (Cbz-Cl, 28.15 g, 0.165 mol) was added slowly with stirring and then the reaction mixture was gradually warmed to room temperature. After continued stirring for 3 h, the reaction mixture was extracted with methyl tert-butyl ether (100 mL). The pH of the aqueous layer was adjusted with aqueous hydrochloric acid to 2. The oil formed was extracted with ethyl acetate (100 mL x 2). The organic layers were combined, washed with water and concentrated under vacuum to give (S)-2-(((benzyloxy)carbonyl)amino)-2-phenylacetic acid (30.2 g, 80% yield) as a white solid. | | References | [1] Tetrahedron Letters, 2006, vol. 47, # 36, p. 6393 - 6396
[2] Patent: WO2018/136647, 2018, A2. Location in patent: Page/Page column 29-30
[3] Tetrahedron Letters, 1993, vol. 34, # 39, p. 6329 - 6332
[4] Patent: WO2014/210436, 2014, A2. Location in patent: Paragraph 00520; 00521
[5] Patent: EP1076563, 2005, B1. Location in patent: Page/Page column 9; 13 |
| | Z-PHG-OH Preparation Products And Raw materials |
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