- Mal-PEG2-acid
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- $0.00 / 5g
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2024-03-27
- CAS:1374666-32-6
- Min. Order: 5g
- Purity: >98.00%
- Supply Ability: 5g
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| | Mal-PEG2-acid Basic information |
| Product Name: | Mal-PEG2-acid | | Synonyms: | Mal-PEG2-acid;Maleimide-PEG2-CH2CH2COOH;Mal-PEG2-CH2CH2COOH;Mal-NH-PEG2-acid;3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic acid;α-Maleimidyl-ω-propionyloxy poly(ethylene glycol);Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-;3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid | | CAS: | 1374666-32-6 | | MF: | C11H15NO6 | | MW: | 257.24 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1374666-32-6.mol |  |
| | Mal-PEG2-acid Chemical Properties |
| Boiling point | 455.7±35.0 °C(Predicted) | | density | 1.329±0.06 g/cm3(Predicted) | | pka | 4.27±0.10(Predicted) | | form | powder to crystal | | color | White to Light yellow | | CAS DataBase Reference | 1374666-32-6 |
| | Mal-PEG2-acid Usage And Synthesis |
| Description | Mal-PEG2-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Biological Activity | Mal-PEG2-acid is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It can bind to Tubulysin (HY-128914) and its cytotoxic derivatives activity. It can also be used as a PROTAC linker for PROTAC synthesis. | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target | | Non-cleavable < span> | PEGs | |
| | Mal-PEG2-acid Preparation Products And Raw materials |
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