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| Product Name: | FIIN-3 | | Synonyms: | FIIN-3;FIN-3;FIIN3; FIIN 3;FIIN3; FIIN 3; FIIN-3;CS-2331;2-Propenamide, N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-;Inhibitor,FIIN 3,FIIN-3,HER1,FIIN3,ErbB-1,Epidermal growth factor receptor,inhibit,Fibroblast growth factor receptor,EGFR,FGFR | | CAS: | 1637735-84-2 | | MF: | C34H36Cl2N8O4 | | MW: | 691.61 | | EINECS: | | | Product Categories: | | | Mol File: | 1637735-84-2.mol |  |
| | FIIN-3 Chemical Properties |
| Boiling point | 909.4±65.0 °C(Predicted) | | density | 1.379±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Acetonitrile: sparingly soluble; Methanol: sparingly soluble | | form | A crystalline solid | | pka | 10.78±0.70(Predicted) |
| | FIIN-3 Usage And Synthesis |
| Description | FIIN-3 is an inhibitor of FGF receptors (FGFRs; IC50s = 13, 21, 31, and 35 nM for recombinant FGFR1-4, respectively). It is selective for FGFRs over a panel of 456 kinases at a concentration of 1 μM, however, it does inhibit EGFR (IC50 = 204 nM). FIIN-3 inhibits growth of Ba/F3 cells that are dependent on the kinase activity of wild-type FGFR1-4 as well as gatekeeper mutant FGFR2 and FGFR3 (EC50s = <1-69 nM) and inhibits FGFR-dependent signaling in a concentration-dependent manner in FGFR2TEL/V564M-dependent Ba/F3 cells. FIIN-3 also inhibits growth in a panel of cancer cell lines (EC50s = 1.4-499 nM). | | Uses | FIIN-?3 is FGFR inhibitor. It can be used in synthetic preparation and complex with EGFR kinase of crystal structure; development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. | | Definition | ChEBI: N-[4-[[[(2,6-dichloro-3,5-dimethoxyanilino)-oxomethyl]-[6-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]amino]methyl]phenyl]-2-propenamide is a member of piperazines. |
| | FIIN-3 Preparation Products And Raw materials |
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