|
|
| Product Name: | R-IMPP | | Synonyms: | R-IMPP;Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl-;PF-00932239 (R-IMPP);(R)-N-(Isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide;Serine endopeptidases,PF-00932239,PF 00932239,inhibit,Ser/Thr Protease,RIMPP,R-IMPP,Inhibitor,Threonine proteases,R IMPP,PF00932239,Serine proteases | | CAS: | 2133832-83-2 | | MF: | C24H27N3O2 | | MW: | 389.49 | | EINECS: | | | Product Categories: | | | Mol File: | 2133832-83-2.mol |  |
| | R-IMPP Chemical Properties |
| Boiling point | 594.4±50.0 °C(Predicted) | | density | 1.186±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 1 mg/ml; DMSO: 10 mg/ml | | form | A crystalline solid | | pka | 9.14±0.10(Predicted) |
| | R-IMPP Usage And Synthesis |
| Description | (R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 μM). It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels. (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation. |
| | R-IMPP Preparation Products And Raw materials |
|