ARV-771 manufacturers
- ARV-771
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- $0.00 / 100MG
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2024-04-19
- CAS:1949837-12-0
- Min. Order: 1MG
- Purity: 98
- Supply Ability: 100G
- ARV-771
-
- $0.00 / 1mg
-
2021-09-29
- CAS:1949837-12-0
- Min. Order: 1mg
- Purity: 98%min
- Supply Ability: 500mg
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| | ARV-771 Basic information |
| Product Name: | ARV-771 | | Synonyms: | ARV-771;ARV 771; ARV771;(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-;(2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide;Epigenetic Reader Domain,ARV-771,ARV771,inhibit,ARV 771,PROTACs,Inhibitor | | CAS: | 1949837-12-0 | | MF: | C49H60ClN9O7S2 | | MW: | 986.65 | | EINECS: | | | Product Categories: | ADC LINKER;API | | Mol File: | 1949837-12-0.mol |  |
| | ARV-771 Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO:65.92(Max Conc. mg/mL);68.22(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);20.7(Max Conc. mM)
DMF:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.14(Max Conc. mM)
Ethanol:55.0(Max Conc. mg/mL);56.92(Max Conc. mM) | | form | A crystalline solid | | pka | 13.61±0.46(Predicted) |
| | ARV-771 Usage And Synthesis |
| Description | ARV-771 is a BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1) and BRD4(2), respectively. | | Uses | ARV-771 is an effective BET degrader of the PROTAC class. | | Biological Activity | ARV-771 is a potent pan-(bromodomain and extra-terminal) BET degrader, a novel BET-PROTAC (proteolysis-targeting chimera), for BRD2(1), BRD2(2), BRD3(1) The Kd values of , BRD3(2), BRD4(1) and BRD4(2) were 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM and 7.6 nM, respectively. | | target | | Target | Value | BRD2-BD2
(Cell-free assay) | 4.7 nM(Kd) | BRD3-BD2
(Cell-free assay) | 7.6 nM(Kd) | td> BRD4-BD2
(Cell-free assay) | 7.6 nM(Kd) | BRD3-BD1
(Cell-free assay) | 8.3 nM(Kd) | BRD4-BD1
(Cell-free assay) | 9.6 nM(Kd) |
| | storage | Store at -20°C |
| | ARV-771 Preparation Products And Raw materials |
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