| Company Name: |
MedChemexpress LLC
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| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:ZK-90055 (hydrochloride)
CAS:84638-81-3
Purity:560RMB/1mg Package:>98%
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ZK-90055 (hydrochloride) manufacturers
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| | ZK-90055 (hydrochloride) Basic information |
| | ZK-90055 (hydrochloride) Chemical Properties |
| Melting point | 187-190 °C (decomp) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | ZK-90055 (hydrochloride) Usage And Synthesis |
| Uses | ZK-90055 hydrochloride is a β2 adrenergic receptor agonist. | | in vivo | Contrasting a pro-drug, a soft-drug is active per se when given locally but is rapidly inactivated when it reaches the general circulation. Thus, a long duration of action at a minimum of systemic side effects may be achieved after inhalation of a h2-agonist designed in this way. One such example is ZK-90055, an indol derivative with a hydrolysable ester bond on the ring system. The development of ZK-90055 is stopped before clinical trials are commenced[2]. | | References | [1] Waldeck B, et al. beta-Adrenoceptor agonists after terbutaline. Pharmacol Toxicol. 1995;77 Suppl 3:25-9. DOI:10.1111/j.1600-0773.1995.tb01937.x
[2] Waldeck B, et al. Beta-adrenoceptor agonists and asthma--100 years of development. Eur J Pharmacol. 2002 Jun 7;445(1-2):1-12. DOI:10.1016/s0014-2999(02)01728-4 |
| | ZK-90055 (hydrochloride) Preparation Products And Raw materials |
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