NGR peptide Trifluoroacetate
| 中文名称 | NGR peptide Trifluoroacetate |
|---|---|
| 中文同义词 | NGR肽(TFA盐) |
| 英文名称 | NGR peptide Trifluoroacetate |
| 英文同义词 | NGR peptide Trifluoroacetate |
| CAS号 | |
| 分子式 | C??H??F?N??O??S? |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
NGR peptide Trifluoroacetate 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 白色至米白色 |
NGR peptide Trifluoroacetate 是含有天冬酰胺-甘氨酸-精氨酸 (NGR) 基序的肽，NGR peptide (NGR 肽) 可靶向肿瘤新生血管上皮细胞特异过量表达的 CD13 受体。
CD13/aminopeptidase N (APN) receptor
NGR peptide can selectively bind to APN/CD13 either immune-captured or expressed on the surface of cells, the receptor of the tumor-homing NGR peptide was suspected to be APN/CD13. The NGR peptide is reported to have the greatest tumor selectivity. An anti-cancer drug Doxorubicin (DOX) coupled to an NGR peptide displays enhanced anti-tumor effects with even lower toxicity than the free drug itself.
NGR peptide imaging in vivo not only provides more insight into NGR’s targeting process, including bio-distribution and pharmacokinetics, but also reveals angiogenic activities related to tumor progression and malignancy.