| Company Name: |
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
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| Tel: |
13892832556 |
| Email: |
2440688701@qq.com |
| Products Intro: |
Product Name:Methyltetrazine-amido-PEG7-azide
CAS:2112731-46-9
Purity:95% HPLC Package:1g;5g;10g;25g;100g;1kg
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| | Methyltetrazine-amido-PEG7-azide Basic information |
| | Methyltetrazine-amido-PEG7-azide Chemical Properties |
| solubility | Soluble in DMSO, DCM, DMF |
| | Methyltetrazine-amido-PEG7-azide Usage And Synthesis |
| Description | Methyltetrazine-amido-PEG7-azide is a bifunctional PEG crosslinker. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene) under miled condition, Azide(N3) group can enable copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. | | Uses | Methyltetrazine-amido-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-amido-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Methyltetrazine-amido-PEG7-azide Preparation Products And Raw materials |
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