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| | PF-9366 Basic information |
| Product Name: | PF-9366 | | Synonyms: | PF-9366;CS-2703;PF-9366; PF 9366; PF9366;72882-78-1;PF 9366 NEW;[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-;2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine;PF-9366,inhibit,PF9366,PF 9366,Inhibitor | | CAS: | 72882-78-1 | | MF: | C20H19ClN4 | | MW: | 350.84 | | EINECS: | | | Product Categories: | API | | Mol File: | 72882-78-1.mol |  |
| | PF-9366 Chemical Properties |
| Melting point | 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 20 mg/ml). | | pka | 8.75±0.28(Predicted) | | form | solid | | color | Beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | PF-9366 Usage And Synthesis |
| Description | PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively. | | Uses | PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform. | | References | 1) Quinlan?et al. (2017),?Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol.,?13?785 |
| | PF-9366 Preparation Products And Raw materials |
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