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Citicoline sodium

Citicoline sodium Suppliers list
Company Name: Hangzhou Weitai Biological Pharmaceutical Co.,Ltd.
Tel: +8613282012786
Email: sales@weitai-pharmaceutical.com
Products Intro: Product Name:Citicoline Sodium (CDPC)
CAS:33818-15-4
Purity:>=99%(Excellent grade) Package:1g;0USD
Company Name: Leading Chemical and Trading Co.,Ltd
Tel: +8615669938129
Email: sales@leadingchemical.com
Products Intro: Product Name:Citicoline sodium
CAS:33818-15-4
Purity:99% Package:1KG,5KG,20KG
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +8613288715578
Email: sales@hbmojin.com
Products Intro: Product Name:Citicoline sodium
CAS:33818-15-4
Purity:99% Package:25KG
Company Name: Hebei Yanxi Chemical Co., Ltd.
Tel: +8617531190177
Email: peter@yan-xi.com
Products Intro: Product Name:Citicoline sodium
CAS:33818-15-4
Purity:0.99 Package:1kg Remarks:Factory direct sales
Company Name: Sinoway Industrial co., ltd.
Tel: 0592-5800732; +8613806035118
Email: xie@china-sinoway.com
Products Intro: Product Name:Citicoline Sodium
CAS:33818-15-4
Purity:99% up / CP2010 / GMP Package:1Kg/Bag;220.00;USD|25Kg/Bag;180.00;USD|100Kg/Bag;160.00;USD

Citicoline sodium manufacturers

  • Citicoline Sodium
  • Citicoline Sodium pictures
  • $220.00 / 1Kg/Bag
  • 2024-03-26
  • CAS:33818-15-4
  • Min. Order: 1Kg/Bag
  • Purity: 99% up / CP2010 / GMP
  • Supply Ability: 20 tons
  • Citicoline sodium
  • Citicoline sodium pictures
  • $0.00 / 1KG
  • 2024-03-16
  • CAS:33818-15-4
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Citicoline sodium
  • Citicoline sodium pictures
  • $9.90 / 10g
  • 2024-01-20
  • CAS:33818-15-4
  • Min. Order: 5g
  • Purity: 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customiz
  • Supply Ability: 100kg

Related articles

  • Side Effect of Citicoline Sodium
  • Citicoline Sodium is generally used to treat various central nervous system diseases caused by accidents of brain injury and t....
  • Sep 27,2021
Citicoline sodium Basic information
Description Application Mechanism of action
Product Name:Citicoline sodium
Synonyms:P'-[2-(TRIMETHYLAMMONIO)ETHYL]ESTER CYTIDINE 5'-(TRIHYDROGEN DIPHOSPHATE) INNER SALT MONOSODIUM;cytidine 5'-(trihydrogen diphosphate) p'-[2-(trimethylammonio)ethyl] ester inner salt monosodium salt;CYTIDINE-5'-DIPHOSPHOCHOLINE MONOSODIUM SALT;CYTIDINE-5'-DIPHOSPHOCHOLINE, NA;CYTIDINE-5'-DIPHOSPHOCHOLINE, SODIUM;CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT;CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE;CITICOLINE SODIUM
CAS:33818-15-4
MF:C14H26N4O11P2.Na
MW:511.31
EINECS:251-689-1
Product Categories:API;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Miscellaneous Natural Products;33818-15-4
Mol File:33818-15-4.mol
Citicoline sodium Structure
Citicoline sodium Chemical Properties
Melting point 259-268°C (dec.)
alpha D20 +12.5° (c = 1.0 in H2O)
storage temp. -20°C
solubility H2O: 100mg/mL
form solid
color white
Water Solubility Soluble in water (100 mg/ml).
λmax280nm(HCl aq.)(lit.)
Merck 13,2343
BRN 4110040
InChIKeyYWAFNFGRBBBSPD-OCMLZEEQSA-M
SMILESO[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C=CC(N)=NC1=O)O.[NaH] |&1:1,2,3,21,r|
CAS DataBase Reference33818-15-4
Safety Information
Safety Statements 24/25
WGK Germany 3
3-10-21
HS Code 29349990
MSDS Information
Citicoline sodium Usage And Synthesis
DescriptionCiticoline is a nucleic acid derivatives, Geiger found that citicoline can restore brain injury in the animal experiments in 1956. Kennedy study confirmed that citicoline can make brain injury recovery in 1957. Takeda pharmaceutical company in Japan developed and produced it in 1961. It was registered in China in 1988, and is currently the best-selling drug among clinical brain diseases. It plays an important role in the synthesis of lecithin, by promoting the synthesis of lecithin and improving brain function. Experiments show that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, thereby it can treat cerebrovascular disease, traumatic brain injury and cognitive impairment caused by various reasons, and there are no obvious side effects.
Application
  • Central nervous system medication.
  • Coenzyme. For acute traumatic brain injury and brain surgery consciousness. Acute brain injury and brain surgery after a disturbance of consciousness, paralysis due to stroke can gradually restore the function of the limbs, it can also be used for functions and other central nervous system disorders of consciousness caused by acute injury, and also for ischemic cerebrovascular disease and vascular dementia.
Mechanism of actionCiticoline sodium can enhance the function of brain stem reticular formation, especially the ascending reticular activating system associated with human consciousness; enhance the function of the pyramidal system; inhibit the function of the external system of the cone, and promotes the recovery of the function of the system. For the treatment of sequelae of traumatic brain injury and cerebral vascular accident caused by the nervous system, it can also be used in the treatment of Parkinson's disease, senile dementia has a certain effect; for the treatment of cardiovascular and cerebrovascular diseases; it also have a certain effect for anti-aging, improving learning and memory.
Chemical PropertiesWhite Solid
UsesCytidine-5'-diphosphocholine sodium salt hydrate acts as a neuroprotective agent in situations of hypoxia and ischemia. It is used as biosynthetic intermediate of membrane phospholipids. It is a cerebral vasodilator and inhibits PLA2 activation.
UsesCytidine 5′-diphosphate (CDP) is used as a substrate of CDP (nucleoside diphosphate) kinase (2.7.4.6) to produce CTP in support ofDNA and RNA biosynthesis and of ribonucleotide reductase to product dCMP.
UsesNaturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma.
ApplicationCiticoline (CDP-choline) is an essential intermediate in the synthesis of the major phospholipid of the cell membranes, phosphatidylcholine (PtdCho). It increases plasma adrenocorticotropic hormone (ACTH) levels and potentiates serum thyrotrophin (TSH) levels by activating the central cholinergic system.
Citicoline Sodium is used to treat age-related memory loss, cerebrovascular diseases such as stroke, dementia, as well as head trauma. Research has shown that it increases a chemical called phosphatidylcholine which is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured. Citicoline Sodium is also said to help with weight management when used as a dietary supplement.
Brand nameCerAxon (Interneuron).
General DescriptionCytidine 5′-diphosphocholine (CDP-choline) contains cytidine and choline linked via a diphosphate bridge.
Biochem/physiol ActionsCytidine 5′-diphosphocholine (CDP-choline) plays an important role in the synthesis of phosphatidylcholine. It is also involved in the biosynthesis of acetylcholine, a neurotransmitter. CDP-choline has therapeutic effects against hypoxia, cerebral ischemia and traumatic brain injury. It also exhibits therapeutic effects against learning and memory disorders, drug addiction and Alzheimer′s and Parkinson′s diseases.
SafetyThere are two forms of citicoline: citicoline sodium and citicoline free-base. Citicoline sodium is the form that is approved as a prescription medication in some European countries and throughout Asia. Citicoline free-base is the form that is available as a dietary supplement and food/beverage ingredient in the United States. In Europe, citicoline is approved as a Novel Food ingredient and is authorized to be used in food supplements up to 500 mg per day. It is also authorized to be used for Food for Special Medical Purposes (FSMPs) in amounts of 250 mg/serving and up to 1,000 mg per day.
Citicoline free-base is produced in Japan by Kyowa Hakko Bio Co. Ltd. under the brand name of Cognizin. Cognizin is considered to be safe and received self-designated Generally Recognized As Safe (GRAS) status in 2009. In Europe, citicoline was approved as a Novel Food ingredient in 2014. Whereas most companies produce citicoline synthetically, Cognizin is produced using a patented, natural fermentation process. It is vegetarian and allergen-free. Kyowa Hakko manufactures and supplies Cognizin as a raw ingredient to many manufacturers around the world.
MetabolismCiticoline can be administered orally, intramuscularly, or intravenously. Oral administration is most common because its bioavailability is approximately 92%. After oral ingestion, citicoline is hydrolyzed in the small intestine and liver into 2 major metabolites: cytidine and choline.
Cytidine and choline enter the systemic circulation, where cytidine is further metabolized into uridine. Both uridine and free choline cross the blood-brain barrier. In the central nervous system, uridine is converted to cytidine triphosphate, choline is converted to phosphocholine, and the 2 combine to resynthesize CDP-choline.
Citicoline sodium Preparation Products And Raw materials
Raw materialsCytidine, 5'-phosphorodichloridate (8CI,9CI)-->CYTIDINE 5'-DIPHOSPHOCHOLINE-->phosphorylcholine-->Cytidine 5’-monophosphate
Tag:Citicoline sodium(33818-15-4) Related Product Information
Sodium chlorite CYTIDINE 5'-DIPHOSPHOCHOLINE Sodium citrate Sodium chloride Sodium benzoate Sodium acetate Sodium hydroxide Tris(trimethylsilyl)phosphate Cytosine Ethyl acrylate SULPHOSUCCINIC ACID ESTER Citiolone Sodium bicarbonate Diclofenac sodium Cytidine Ethyl acetate Trisodium phosphate Ethylparaben