- UV-284 Benzophenone-4
-
- $120.00 / 1kg
-
2024-04-26
- CAS:4065-45-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20ton
- Benzophenone-4
-
- $40.00 / 1kg
-
2024-04-26
- CAS:4065-45-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000kg/week
|
| | 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Basic information |
| | 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Chemical Properties |
| Melting point | 170 °C | | Boiling point | 0°C | | density | 1.4574 (rough estimate) | | vapor pressure | 0Pa at 25℃ | | refractive index | 1.5300 (estimate) | | Fp | 0°C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | -0.70±0.50(Predicted) | | color | White to Off-White | | Water Solubility | 300.92g/L at 25℃ | | Merck | 14,8983 | | BRN | 2889165 | | InChIKey | CXVGEDCSTKKODG-UHFFFAOYSA-N | | LogP | 0.515 at 25℃ | | CAS DataBase Reference | 4065-45-6(CAS DataBase Reference) | | EPA Substance Registry System | Sulisobenzone (4065-45-6) |
| | 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Usage And Synthesis |
| Chemical Properties | white to yellowish powder | | Originator | Uval,Dome,US,1965 | | Uses | sulisobenzone is the drug name for benzophenone-4, a sunscreen chemical. | | Uses | Ultraviolet absorber for leather and textile fibers; in cosmetics and shampoos. | | Uses | ultraviolet screen | | Uses | 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a commonly used, FDA approved sunscreen chemical with uVA-absorbing properties and an approved usage level of 5 to 10 percent. It protects a formulation from the effects of uV-light exposure. | | Definition | ChEBI: Sulisobenzone is a member of benzophenones. | | Manufacturing Process | 663 g of dichloroethane and 74.6 g 2-hydroxy-4-methoxybenzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux
condenser and dropping funnel and a heating mantle. The solution was heated
to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off
66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic
acid was added slowly over a period of about two hours. The rate of addition
was regulated by the speed of evolution of the HCl. After all the chlorosulfonic
acid was added, the charge was still maintained at reflux for an additional 15
minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The
filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of
product were obtained. | | Brand name | Sungard (Bayer). | | Therapeutic Function | Sunscreen agent | | General Description | Sulisobenzone is a broad spectrum organic UV filter in sunscreen formulations, known to absorb deleterious UV light. | | Flammability and Explosibility | Non flammable | | Contact allergens | BZP-4 is widely used in cosmetics, particularly shampoos
and hair products. Cross-reactivity is rarely
expected in patients photoallergic to ketoprofen. |
| | 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Preparation Products And Raw materials |
|