| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Fibroblast Growth Factor-4
Purity:FGF-4, E. coli, lyophilized powder, cell culture Package:25μg Remarks:F8424
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| Company Name: |
Creative Peptides
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| Tel: |
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| Email: |
info@creative-peptides.com |
| Products Intro: |
Product Name:K-FGF
Purity:>98% Package:1g; 10g;100g;1kg
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| Company Name: |
Shanghai Kanglang Biotechnology Co., Ltd.
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| Tel: |
021-61998208 18217752821 |
| Email: |
sales@klbio.cn |
| Products Intro: |
Product Name:Recombinant Human FGF-4
Purity:99.99% Package:5μg/646;25μg/1613;100μg/5925;1mg/18967
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| Product Name: | HUMAN FGF-4 | | Synonyms: | RECOMBINANT HUMAN FGF-4;FIBROBLAST GROWTH FACTOR-4, HUMAN;FIBROBLAST GROWTH FACTOR-4;FGF-4, HUMAN;FGF-4;FIBROBLAST GROWTH FACTOR-4 HUMAN, RECOMBINANT;HUMAN FGF-4;HUMAN FIBROBLAST GROWTH FACTOR 4 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | Human | | Mol File: | Mol File | ![HUMAN FGF-4 Structure]() |
| | HUMAN FGF-4 Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder | | biological source | human |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | HUMAN FGF-4 Usage And Synthesis |
| Uses | Fibroblast Growth Factor-4 human has been used:
- To maintain trophectoderm stem cells.
- In neurogenic differentiation.
- In hepatocyte differentiation.
| | General Description | Fibroblast Growth Factor-4 (FGF4) is a 19 kDa protein, belonging to the FGF family of proteins. Fibroblast growth factors (FGF) are glycoproteins concealed in the extracellular matrix and cell surface. There are around 22 different types of FGFs known. These factors weigh in the range of 17 to 34 kDa and they possess a conserved sequence of 120 amino acids. The FGF4 gene is mapped to human chromosome 11q13.3. | | Biochem/physiol Actions | Fibroblast growth factor-4 (FGF-4) is identified in NIH-3T3 cell assays as a transforming gene from DNA derived from human tumors, including stomach (hst) and colon cancers, Kaposi′s sarcoma, and hepatocellular carcinoma. FGF-4 includes a secretory signal sequence and shares 42% sequence identity with FGF-Basic at the amino acid level. Both FGF-4 and FGF-Basic bind to the same receptors. Mouse and human FGF-4 shares 82% homology with species cross-reactivity. FGF-4 does not appear to be expressed in normal adult tissues, but during embryogenesis, the gene is spatially and temporally regulated. FGF-4 is a mitogen for fibroblasts and endothelial cells and a potent promoter of angiogenesis. It is believed to be critical in embryonic limb development. FGF-4 participates in cell differentiation and cell migration. | | Description | FGF4 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 182 amino acids and having a molecular mass of 19.8kDa. The FGF4 is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | FGF4 holds s comprehensive mitogenic and cell survival activities and takes part in a range of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF4 possess oncogenic transforming activity. FGF4 and FGF3, oncogenic growth factors are localized on chromosome 11. Co-amplification of both factors was found in several kinds of human tumors. FGF4 functions in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. |
| | HUMAN FGF-4 Preparation Products And Raw materials |
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