2',4'-Dihydroxy-2-phenylacetophenone manufacturers
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| | 2',4'-Dihydroxy-2-phenylacetophenone Basic information |
| | 2',4'-Dihydroxy-2-phenylacetophenone Chemical Properties |
| Melting point | 112-116 °C(lit.) | | Boiling point | 225°C/10mmHg(lit.) | | density | 1.278±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 7.74±0.35(Predicted) | | color | White to Light yellow to Light orange | | CAS DataBase Reference | 3669-41-8(CAS DataBase Reference) | | NIST Chemistry Reference | 2,4-Dihydroxyphenylbenzyl ketone(3669-41-8) |
| | 2',4'-Dihydroxy-2-phenylacetophenone Usage And Synthesis |
| Chemical Properties | off-white crystalline powder | | Uses | 1-(2,4-Dihydroxyphenyl)-2-phenylethanone is used in preparation of substituted pyrazoles, pyrimidines, triazoles and related heterocycles as c-MYC targeting agents for treatment of cancer and other proliferative diseases. | | Preparation | Preparation by Friedel–Crafts acylation of resorcinol with phenylacetyl chloride in the presence of aluminium chloride,
? in methylene chloride (85%) ;
? in nitrobenzene at 70–80° for 15 min (<80%), at r.t. for 24 h (63%) or for 2 days (60%);
? in ethyl ether at r.t. for 24 h (43%). |
| | 2',4'-Dihydroxy-2-phenylacetophenone Preparation Products And Raw materials |
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