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(1S,2S)-(+)-Pseudoephedrine hydrochloride

(1S,2S)-(+)-Pseudoephedrine hydrochloride Basic information
Product Name:(1S,2S)-(+)-Pseudoephedrine hydrochloride
Synonyms:(+)-PSI-EPHEDRINE HYDROCHLORIDE;PSI-EPHEDRINE HYDROCHLORIDE;PSEUDOEPHEDRINE HCL, (+)-1S,2S-;(+)-PSEUDOEPHEDRINE HYDROCHLORIDE;a)]-;alpha-(1-(methylamino)ethyl)-,hydrochloride,(s-(r*,r*))-benzenemethano;benzenemethanol,alpha-[1-(methylamino)ethyl]-,hydrochloride,[s-(theta,thet;hydrochloride,l-(+)-pseudoephedrin
CAS:345-78-8
MF:C10H16ClNO
MW:201.69
EINECS:206-462-1
Product Categories:Pharmaceutical Raw Materials;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;API's
Mol File:345-78-8.mol
(1S,2S)-(+)-Pseudoephedrine hydrochloride Structure
(1S,2S)-(+)-Pseudoephedrine hydrochloride Chemical Properties
Melting point 185-188 °C(lit.)
alpha 61 º (c=5, H2O,2dm tube)
storage temp. Refrigerator (+4°C)
solubility Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride.
pka9.22(at 25℃)
Merck 13,8007
BRN 3915112
LogP-1.74 at 23℃ and pH7
CAS DataBase Reference345-78-8(CAS DataBase Reference)
EPA Substance Registry SystemBenzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (345-78-8)
Safety Information
Hazard Codes Xn,T,F
Risk Statements 22-36/37/38-36/38-39/23/24/25-23/24/25-11
Safety Statements 26-36-24/25-45-36/37-16-7
RIDADR 1544
WGK Germany 3
RTECS UL5950000
HazardClass 6.1(b)
PackingGroup III
HS Code 29394200
ToxicityLD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles)
MSDS Information
ProviderLanguage
(1S,2S)-(+)-Pseudoephedrine hydrochloride English
SigmaAldrich English
(1S,2S)-(+)-Pseudoephedrine hydrochloride Usage And Synthesis
Chemical Propertieswhite powder
UsesNon-selective adrenergic agonist; decongestant (nasal). Controlled precursor.
DefinitionChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine.
Brand nameEfidac (ALZA); Novafed (Sanofi Aventis); Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert).
Contact allergensThis sympathomimetic a-adrenergic agonist is found in plants of the genus Ephedra (Ephedraceae) and is systemically used as a nasal decongestant. It can induce drug skin reactions such as acute generalized exanthematic pustulosis or generalized eczema.
Clinical UseNasal decongestant
Drug interactionsPotentially hazardous interactions with other drugs
Adrenergic neurone blockers: antagonise hypotensive effect of adrenergic neurone blockers.
Anaesthetics: increased risk of ventricular arrhythmias with isoflurane.
Antibacterials: risk of hypertensive crisis with linezolid.
Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide.
Dopaminergics: avoid concomitant use with selegiline and rasagiline.
MetabolismA small amount of pseudoephedrine is hepatically metabolised by N-demethylation.
It is excreted largely unchanged in the urine with small amounts of its hepatic metabolite.
Purification Methods1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.]
(1S,2S)-(+)-Pseudoephedrine hydrochloride Preparation Products And Raw materials
Tag:(1S,2S)-(+)-Pseudoephedrine hydrochloride(345-78-8) Related Product Information
Pseudoephedrine sulfate PHENDIMETRAZINE BITARTRATE PHENDIMETRAZINE (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole 4-(4-Chlorophenyl)piperidin-4-ol Haloperidol 4-HYDROXY-4-PHENYLPIPERIDINE (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE 4-(3-Trifuoromethyl)phenyl-4-piperidinol 4-[3-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL HYDROCHLORIDE (S)-(-)-ALPHA,ALPHA-DI(2-NAPHTHYL)-2-PYRROLIDINEMETHANOL (1S,2S)-(+)-Pseudoephedrine hydrochloride P-CHLORO-NOR-PSEUDOEPHEDRINE HYDROCHLORIDE Pseudoephedrine Ephedrine hydrochloride Ephedrine HALOPERIDOL METABOLITE II Pseudoephedrine Hcl Pseudoephedrine Hydrochloride