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| | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Basic information |
| | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Chemical Properties |
| Melting point | 86-88 | | Boiling point | 281.4±36.0 °C(Predicted) | | density | 1.070±0.06 g/cm3(Predicted) | | vapor pressure | 0.049Pa at 20℃ | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in chloroform and dichloromethane. | | form | powder to crystal | | pka | 6.19±0.70(Predicted) | | color | Light yellow to Brown | | InChIKey | MZLRFUCMBQWLNV-FNORWQNLSA-N | | LogP | 0.26 at 20℃ and pH7.2 | | Surface tension | 71.8mN/m at 1.008g/L and 20℃ | | CAS DataBase Reference | 55314-16-4(CAS DataBase Reference) |
| | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Usage And Synthesis |
| Description | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours. | | Chemical Properties | Off-White Solid | | Uses | 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate. | | Uses | Rasagiline intermediate | | Solubility in organics | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane. |
| | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Preparation Products And Raw materials |
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