- Pyridazin-3-amine
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- $1.10 / 1g
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2025-11-18
- CAS:5469-70-5
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- aminopyridazine
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- $200.00 / 1KG
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2025-09-25
- CAS:5469-70-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- Pyridazin-3-amine
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- $0.00 / 1KG
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2025-04-04
- CAS:5469-70-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
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| | Pyridazin-3-amine Basic information |
| | Pyridazin-3-amine Chemical Properties |
| Melting point | 171 °C | | Boiling point | 326.2±15.0 °C(Predicted) | | density | 1.216±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | Solid | | pka | 4.88±0.10(Predicted) | | color | White to pale yellow | | InChI | InChI=1S/C4H5N3/c5-4-2-1-3-6-7-4/h1-3H,(H2,5,7) | | InChIKey | LETVJWLLIMJADE-UHFFFAOYSA-N | | SMILES | C1(N)=NN=CC=C1 | | CAS DataBase Reference | 5469-70-5(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-36 | | Safety Statements | 26-24/25 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 |
| | Pyridazin-3-amine Usage And Synthesis |
| Chemical Properties | White to yellow to light brown powder or crystal | | Uses | It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. | | Synthesis | General procedure for the synthesis of pyridazin-3-amine from 3-amino-6-chloropyridazine:
(1) 6-chloropyridazin-3-amine (5.00 g, 38.6 mmol), tetrahydrofuran (240 mL), sodium hydroxide (8.00 g, 200 mmol), water (32 mL), and 10% palladium-carbon catalyst (500 mg) were mixed, and the reaction was stirred at room temperature in a hydrogen atmosphere for 2 days. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated. The residue was dissolved in methanol (100 mL), filtered again to remove insoluble matter, and the filtrate was concentrated to quantitatively obtain the target product pyridazin-3-amine as a solid.
1H-NMR (DMSO-d6) δ: 2.51 (2H, broad peak), 6.46-6.49 (1H, multiple peaks), 6.93-6.97 (1H, multiple peaks), 8.06-8.08 (1H, multiple peaks). | | References | [1] Patent: EP1813606, 2007, A1. Location in patent: Page/Page column 82
[2] European Journal of Medicinal Chemistry, 2015, vol. 105, p. 80 - 105
[3] Patent: US2011/9405, 2011, A1. Location in patent: Page/Page column 48
[4] Tetrahedron, 1993, vol. 49, # 3, p. 599 - 606
[5] Patent: US2008/261941, 2008, A1. Location in patent: Page/Page column 29 |
| | Pyridazin-3-amine Preparation Products And Raw materials |
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