| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:O-1918;1,3-DiMethoxy-5-Methyl-2-[(1R,6R)-3-Methyl-6-(1-Methylethenyl)-2-cyclohexen-1-yl]benzene
CAS:536697-79-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:O-1918
CAS:536697-79-7
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:O-1918
CAS:536697-79-7
Purity:≥97% by HPLC Remarks:O-1918 is a cannabidiol analog and a selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. It is also an inhibitor of GPR18. It does not bind t
|
|
| Product Name: | O-1918 | | Synonyms: | O-1918;1,3-DIMETHOXY-5-METHYL-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-BENZENE;Benzene, 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]- | | CAS: | 536697-79-7 | | MF: | C19H26O2 | | MW: | 286.41 | | EINECS: | | | Product Categories: | | | Mol File: | 536697-79-7.mol |  |
| | O-1918 Chemical Properties |
| Boiling point | 383.9±42.0 °C(Predicted) | | density | 0.981±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO > 10 mM | | form | Powder |
| | O-1918 Usage And Synthesis |
| Uses | O-1918 is a cannabidiol analog and a selective antagonist at the endothelial cannabidiol receptor. It is an inhibitor of GPR18. O-1918 can also induce endothelium-dependent vasodilation. | | Biological Activity | Selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB 1 or CB 2 receptors. Inhibits vasodilation and cell migration induced by abnormal-cannabidiol (abn-CBD; 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol). | | Enzyme inhibitor | This endocannabinoid antagonist (FW = 286.42 g/mol; CAS 536697-79-7), systematically named 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1- methylethenyl)-2-cyclohexen-1-yl]benzene, is a cannabidinodiol analogue that selectively targets a putative G-coupled endothelial anandamide receptor that is distinct from CB1 or CB2 endocannabinoid receptors. O- 1918 does not bind to CB1 or CB2 receptors and does not cause vasorelaxation at concentrations up to 30 μM, but inhibits the vasorelaxant effects of abn-cbd and anandamide in a concentration-dependent manner (1- 30 μM). (See abn-cbd; Anandamide; Oleamide). While the atypical cannabinoids O-1602 and abn-cbd (or abnormal cannabidiol) stimulate GPR55-dependent GTPgS activity (EC50 ~ 2 nM), O-1918 antagonizes such effects. O-1918 is involved in the delayed hypotension induced by anandamide in anaesthetized rats. | | storage | Store at -20°C |
| | O-1918 Preparation Products And Raw materials |
|