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Losartan potassium

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Products Intro: Product Name:Losartan potassium
CAS:124750-99-8
Purity:0.99 Package:25KG,5KG;1KG;500G
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Products Intro: Product Name:Losartan potassium 124750-99-8
CAS:124750-99-8
Purity:99% Package:1KG;10USD
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Products Intro: Product Name:Losartan potassium
CAS:124750-99-8
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
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Products Intro: Product Name:Losartan potassium
CAS:124750-99-8
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Lastest Price from Losartan potassium manufacturers

  • Losartan potassium
  • US $0.00-0.00 / 公斤
  • 2020-05-09
  • CAS:124750-99-8
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 600 MT
  • Losartan potassium
  • US $0.00 / KG
  • 2019-10-30
  • CAS:124750-99-8
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 1 ton
Losartan potassium Basic information
Description References
Product Name:Losartan potassium
Synonyms:2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL;2-butyl-4-chloro-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol monopotassium salt;2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOLE-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL, POTASSIUM SALT;LOSARTAN MONOPOTASSIUM SALT;LOSARTAN POTASSIUM;LOSARTAN POTASSIUM SALT;MK 954;1h-imidazole-5-methanol,2-butyl-4-chloro-1-((2’-(1h-tetrazol-5-yl)(1,1’-biphe
CAS:124750-99-8
MF:C22H23ClKN6O
MW:462.01
EINECS:200-287-4
Product Categories:API;Cardiovascular APIs;API Reference Standard;COZAAR;Aromatics;Heterocycles;APIS;Hypertension;Intermediates & Fine Chemicals;Pharmaceuticals;Losartan
Mol File:124750-99-8.mol
Losartan potassium Structure
Losartan potassium Chemical Properties
Melting point 263-265°C
storage temp. Desiccate at RT
solubility Freely soluble in water and in methanol, slightly soluble in acetonitrile.
form powder or crystals
Merck 14,5583
BRN 5845770
InChIKeyOXCMYAYHXIHQOA-UHFFFAOYSA-N
CAS DataBase Reference124750-99-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/37/39
WGK Germany 3
RTECS NI6755100
HS Code 2933290000
Hazardous Substances Data124750-99-8(Hazardous Substances Data)
MSDS Information
Losartan potassium Usage And Synthesis
DescriptionAs a angiotensin II receptor antagonist, Losartan Potassium is the potassium salt of losartan with antihypertensive activity, which is mainly used in the therapy of high blood pressure (hypertension) and diabetic nephropathy. It functions by relaxing blood vessels so that blood can flow more easily. It is also effective to help protect the kidneys from damage caused by diabetes and lower the risks of stroke in patients suffering from hypertension and myocardial enlargement. Besides, recent study has suggested that losartan is beneficial to reverse age related dysfunction in maintaining normal blood pressure and cellular energy usage on mitochondria and it can probably be used to treat left ventricular hypertrophy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.
Referenceshttps://en.wikipedia.org/wiki/Losartan
https://www.drugbank.ca/drugs/DB00678
https://pubchem.ncbi.nlm.nih.gov/compound/11751549#section=Top
http://www.medicinenet.com/losartan-oral/article.htm
DescriptionLosartan potassium is the first potent and selective non-peptide angiotensin II (AT II) AT1 receptor antagonist introduced to the market as a once-daily oral antihypertensive. It is efficacious and long lasting in controlling blood pressure in spontaneous hypertensive rats, in patients with essential hypertension in addition to those patients with renal impairment. Since losartan functions by competitive antagonism at the level of receptor, which represents the most direct way of selectively inhibiting the renin-angiotensin system (RAS) independent of the source of AT II, its use has been reported to be free of the coughing side effect exhibited by the ACE inhibitors. In contrast to calcium channel blockers, losartan does not appear to cause ankle edema, headache and tachycardia. It is also reported to be in clinical trials for the treatment of heart failure. Other reports indicate that losartan may have potential efficacy as an anxiolytic, an antiglaucoma agent, in addition to in providing protection against stroke and in preventing the myointimal proliferative response of the vascular wall after coronary angioplasty and surgery.
Chemical PropertiesWhite to Off-White Crystalline Powder
OriginatorDuPont Merck (U.S.A.)
UsesA nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Usesantihypertensive, AT1 angiotensin II antagonist
UsesCoronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).
Brand nameCozaar (Merck).
Biological ActivitySelective non-peptide angiotensin AT 1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA 2 = 8.27). Orally active antihypertensive agent.
Losartan potassium Preparation Products And Raw materials
Tag:Losartan potassium(124750-99-8) Related Product Information
Losartan potassium Thiophanate-methyl Losartan Nitrotetrazolium blue chloride Difluorochloromethane Kresoxim-methyl Methyl Potassium persulfate Methyl salicylate Biphenyl Potassium sorbate 2,3,5-Triphenyltetrazolium chloride Potassium nitrate Tribenuron methyl Potassium Citrate Tetrazole METSULFURON METHYL Potassium