- N-Fmoc-N'-Boc-L-Lysine
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- $5.00 / 25kg
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2024-04-19
- CAS:71989-26-9
- Min. Order: 1kg
- Purity: ≥99%
- Supply Ability: 100mt/year
- Fmoc-L-Lys(Boc)-OH
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- $0.00/ kg
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2024-04-18
- CAS:71989-26-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T
- Fmoc-Lys(Boc)-OH
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- $5.00 / 1kg
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2024-04-16
- CAS:71989-26-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | Fmoc-Lys(Boc)-OH Basic information |
| | Fmoc-Lys(Boc)-OH Chemical Properties |
| Melting point | 130-135 °C (dec.) | | alpha | -12 º (c=2,DMF 24 ºC) | | Boiling point | 570.69°C (rough estimate) | | density | 1.2301 (rough estimate) | | refractive index | -12 ° (C=1, DMF) | | storage temp. | Store below +30°C. | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | pka | 3.88±0.21(Predicted) | | form | Powder | | color | White | | optical activity | [α]20/D 12±1°, c = 1% in DMF | | Water Solubility | Slightly soluble in water. | | BRN | 4217767 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChIKey | UMRUUWFGLGNQLI-QFIPXVFZSA-N | | CAS DataBase Reference | 71989-26-9(CAS DataBase Reference) |
| | Fmoc-Lys(Boc)-OH Usage And Synthesis |
| Description | Fmoc-Lys(Boc)-OH (Na-Fmoc-Ne-Boc-L-lysine) has emerged as the standard Fmoc-Lys derivative used in peptide synthesis. The Boc group on the side chain is stable under basic conditions and remains in place even through many Fmoc deprotection cycles. The Boc group of Fmoc-Lys(Boc)-OH is readily removed with trifluoroacetic acid (TFA) during cleavage of the peptide product from Wang resin or Rink amide resin. It could self-assemble to sphere like morphology in all conditions irrespective of concentration and heating. To prepare the FAPI-04 dimer complex, this compound could used as a linker to conjugate two FAPI-04 structures by an amide reaction. After further modification, the product can perform cancer theranostics[1-2]. | | Chemical Properties | white to light yellow crystal powde | | Uses | Fmoc-Lys(Boc)-OH can be used for:
- The solid-phase synthesis of pentasubstituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts by coupling with p-methylbenzhydrylamine (MBHA) resin.
- Fmoc-based peptide synthesis of bis-naphthalene diimide, a threading intercalator.
- Synthesis of ε-Boc-ε-(3,5-bis-trifluoromethyl-benzyl)-α-Fmoc-L-Lysine to be used as 19F NMR based screening tool.
| | Uses | It is used to prepare dimeric RGD peptide-paclitaxel conjugate as model for integrin-targeted drug delivery. It is also used to synthesize DOTA-conjugated multivalent cyclic-RGD peptide dendrimers for tumor targeting and imaging use. | | References | [1] Gour N, et al. Controlled aggregation properties of modified single amino acids. ChemRxiv, 2021; 46.
[2] Zhong X, et al. Synthesis and Preclinical Evaluation of a Novel FAPI-04 Dimer for Cancer Theranostics. Molecular Pharmaceutics, 2023; 20: 2402–2414. |
| | Fmoc-Lys(Boc)-OH Preparation Products And Raw materials |
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