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N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA

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N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:SB 334867 hydrochloride
CAS:249889-64-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:SB-334867
CAS:249889-64-3
Purity:95%-99% crystal Liu Package:1KG;0.01USD
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Products Intro: Product Name:SB-334867 HCl
CAS:249889-64-3
Purity:98% Package:5mg Remarks:V1309
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Products Intro: Product Name:1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea
CAS:249889-64-3
Purity:NLT 98% Package:1G;1KG;100KG Remarks:CM30956
Company Name: Amadis Chemical Company Limited
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Products Intro: Product Name:SB-334867
CAS:249889-64-3
Purity:0.97 Package:mgs,gs,kgs Remarks:A911891
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Basic information
Product Name:N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
Synonyms:N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA;SB 334867;Zinc00008794;Urea, N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, (Hydrochloride);SB 334867 hydrochloride NEW;SB334867 HCl;SB-334867 hydrochloride;CS-1473
CAS:249889-64-3
MF:C17H13N5O2
MW:319.32
EINECS:604-604-1
Product Categories:Orexin receptor
Mol File:249889-64-3.mol
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Structure
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Chemical Properties
Melting point >235°C (dec.)
storage temp. Desiccate at RT
solubility Dichloromethane (Slightly), DMSO (Slightly)
form Solid
color White
Safety Information
MSDS Information
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Usage And Synthesis
UsesSB 334867 is an orexin-1-receptor antagonist. An important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability.
DefinitionChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.
Biological ActivitySelective non-peptide orexin OX 1 receptor antagonist. pK b values are 7.2 and < 5 for inhibition of intracellular Ca 2+ release in CHO cells expressing human OX 1 and OX 2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo .
references[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Preparation Products And Raw materials
Tag:N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA(249889-64-3) Related Product Information
1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride 1,5-NAPHTHYRIDIN-4-AMINE N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA