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TP0427736

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TP0427736 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:TP0427736；TP427736;TP-0427736;TP-427736
CAS:864374-00-5
Package:1 mg；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:TP0427736
CAS:864374-00-5
Purity:98% Package:5mg Remarks:V3718
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:TP0427736
CAS:864374-00-5
Purity:98% HPLC Package:100mg，500mg，1g，5g，10g
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:TP0427736 HCl
CAS:864374-00-5
Purity:98% Package:$329.9/5mg;$446.9/10mg;$866.9/25mg;$1373.9/50mg;$2197.9/100mg;$3433.9/200mg;Bulk Remarks:98%
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  
Tel: 020-39119399 18927568969
Email: isunpharm@qq.com
Products Intro: Product Name:TP0427736
CAS:864374-00-5
Purity:98.5% Package:1G; 25G; 1KG; 25KG
TP0427736 Basic information
Product Name:TP0427736
Synonyms:TP0427736;TP0427736 HCl;TP427736;TP-427736;Benzothiazole, 6-[5-(4-methyl-2-thiazolyl)-1H-imidazol-4-yl]-
CAS:864374-00-5
MF:C14H10N4S2
MW:298.39
EINECS:
Product Categories:
Mol File:864374-00-5.mol
TP0427736 Structure
TP0427736 Chemical Properties
Boiling point 634.7±65.0 °C(Predicted)
density 1.439±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 67 mg/mL (200.09 mM);Ethanol: Insoluble
pka9.70±0.10(Predicted)
Water Solubility Water: Insoluble
Safety Information
MSDS Information
TP0427736 Usage And Synthesis
Biological ActivityTP0427736 is a potent ALK5 kinase inhibitor with IC50 of 2.72 nM and IC50 of 836 nM for ALK3. It also inhibits TGF-β1-induced phosphorylation of Smad2/3 in A549 cells with IC50 of 8.68 nM.
in vitro

TP0427736 can inhibit Smad2/3 phosphorylation in a concentration-dependent manner with IC50 of 8.68 nM. In outer root sheath cells, it rescued the inhibition of cell proliferation by TGF-β1 and TGF-β2.

in vivo

TP0427736 reduces hair follicle length shortening during the transition from anagen to catagen.

target
TargetValue
ALK5
(Cell-free assay)		 2.72 nM
TP0427736 Preparation Products And Raw materials
Tag:TP0427736(864374-00-5) Related Product Information
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