- Fmoc-L-Tyr(me)
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- $0.00 / 1kg
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2024-04-25
- CAS:77128-72-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T
- FMOC-TYR(ME)-OH
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- $1.00 / 1KG
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2019-07-06
- CAS:77128-72-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20kg
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| | Fmoc-Tyr(Me)-OH Basic information |
| | Fmoc-Tyr(Me)-OH Chemical Properties |
| Melting point | 161 °C | | Boiling point | 647.8±55.0 °C(Predicted) | | density | 1.274±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | form | powder to crystal | | pka | 2.97±0.10(Predicted) | | color | White to Almost white | | InChIKey | JYQODLWFOPCSCS-QHCPKHFHSA-N | | SMILES | C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O | | CAS DataBase Reference | 77128-72-4(CAS DataBase Reference) |
| WGK Germany | WGK 2 water endangering | | HazardClass | IRRITANT | | HS Code | 29242990 |
| | Fmoc-Tyr(Me)-OH Usage And Synthesis |
| Description | Fmoc-Tyr(Me)-OH, also known as Fmoc-O-methyl-L-tyrosine, is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group. | | Chemical Properties | White to off-white powder | | Synthesis | Fmoc-Tyr(Me)-OH, also known as Fmoc-Tyr(OMe)-OH, was obtained from Fmoc-Tyr(OMe)-OMe within 1h and was isolated following protocol 1 or 2 in 96% yield[1]. Under argon atmosphere, anhydrous THF (2.0 mL) was added to the protected amino acid Fmoc-Tyr(OMe)-OMe (0.12 mmol) and to MgI2 * (1.2 mmol). The suspension was heated in a sealed reactor using microwave irradiation at 120°C. A Na2S2O3 aqueous solution (0.1 M) was then added and the resulting homogeneous mixture was directly analysed by analytical HPLC and LC/MS. To isolate the product, two protocols could be applied:
Protocol 1: The crude material was purified by preparative HPLC.
Protocol 2: The crude material was extracted with AcOEt (x3). The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was diluted in H2O/EtOH and lyophilized. | | References | [1] Berthet M, et al. MgI2 -Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies. Chemistry - A European Journal, 2015; 21: 11014-11016.
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| | Fmoc-Tyr(Me)-OH Preparation Products And Raw materials |
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