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| Product Name: | HS1371 | | Synonyms: | HS1371;CS-2831;HS-1371; HS 1371; HS1371;2158197-70-5;Quinoline, 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-;HS-1371,Inhibitor,Receptor-interacting protein kinases,RIPK,inhibit,HS 1371,RIP kinase,HS1371;7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline | | CAS: | 2158197-70-5 | | MF: | C24H24N4O | | MW: | 384.47 | | EINECS: | | | Product Categories: | API | | Mol File: | 2158197-70-5.mol |  |
| | HS1371 Chemical Properties |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMF:30.0(Max Conc. mg/mL);78.03(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.52(Max Conc. mM)
DMSO:11.56(Max Conc. mg/mL);30.06(Max Conc. mM)
Ethanol:4.5(Max Conc. mg/mL);11.7(Max Conc. mM) | | form | A solid | | color | White to off-white |
| | HS1371 Usage And Synthesis |
| Biological Activity | HS1371 is a potent RIP3 kinase inhibitor with IC50 of 20.8 nM. It binds to the ATP-binding region of RIP3, thereby preventing ATP binding, inhibiting the enzymatic activity of RIP3 in vitro. | | in vitro | HS1371 inhibits autorenal phosphorylation of RIP3 at S227. In HT-29 cells, it has full inhibitory activity on TNF-induced necroptosis signaling and is inactive on the phosphorylation of RIP3 and MLKL. It protects cells from RIP3-dependent necrotic cell death but does not affect apoptotic cell death. | | target | | Target | Value | RIP3 kinase
() | 20.8 nM |
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| | HS1371 Preparation Products And Raw materials |
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