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| | HS-10296 Basic information |
| Product Name: | HS-10296 | | Synonyms: | HS-10296;N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide;HS-10296;HS 10296;HS10296;1899921-05-1;HS 10296;HS10296;Almonertinib (HS-10296);Almonertinib;2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-;N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide | | CAS: | 1899921-05-1 | | MF: | C30H35N7O2 | | MW: | 525.66 | | EINECS: | | | Product Categories: | | | Mol File: | 1899921-05-1.mol |  |
| | HS-10296 Chemical Properties |
| density | 1.24±0.1 g/cm3(Predicted) | | solubility | DMSO:91.67(Max Conc. mg/mL);174.38(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);11.41(Max Conc. mM) | | pka | 12.68±0.70(Predicted) |
| | HS-10296 Usage And Synthesis |
| Uses | Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer. | | Mechanism of action | Almonertinib inhibits EGFR tyrosine kinase targeting EGFR-sensitizing and T790M resistance mutations. |
| | HS-10296 Preparation Products And Raw materials |
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