ChemicalBook > Product Catalog >API >Digestive system drugs >Liver Disease drugs >Glycyrrhizic acid ammonium salt

Glycyrrhizic acid ammonium salt

Glycyrrhizic acid ammonium salt Suppliers list
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: 18080483897 18482058008
Email: maggie@biopurify.com
Products Intro: Product Name:Monoammonium glycyrrhizinate
CAS:53956-04-0
Purity:90%~98% HPLC Package:20mg;100mg;500mg;1g Remarks:BP0956
Company Name: Shanghai Standard Technology Co., Ltd.
Tel: 18502101150
Email: ft-sales@nature-standard.com
Products Intro: Product Name:Glycyrrhizic acid ammonium salt
CAS:53956-04-0
Purity:Analytical Standard Package:20mg;USD
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Glycyrrhizic acid ammonium salt
CAS:53956-04-0
Purity:99% Package:100g ,1KG ,5KG 25KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:Glycyrrhizic acid ammonium salt
CAS:53956-04-0
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Shanghai Time Chemicals CO., Ltd.
Tel: +86-021-57951555 +8618017249410
Email: jack.li@time-chemicals.com
Products Intro: Product Name:Glycyrrhizic acid ammonium salt
CAS:53956-04-0

Glycyrrhizic acid ammonium salt manufacturers

Glycyrrhizic acid ammonium salt Basic information
Product Name:Glycyrrhizic acid ammonium salt
Synonyms:monoammoniumglycyrrhetat;Monoammoniumglycyrrhetate;monoammoniumglycyrrhizate;(2S,3S,4S,5R,6S)-6-[[(3S,4aS,6aR,6bS,8aR,11S,12aR,14aS,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-oxan-2-yl]oxy-3,4-dihydroxyoxane-2-carboxylic acid azane;alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en- 3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniate;20β-Carboxy-11-oxo-30-noroleana-12-ene-3β-yl 2-O-(β-D-glucopyranuronosyl)-α-D-glucopyranosiduronic acid/ammonia,(1:x);Glycyrrhizine ammonium salt;AMMONIUM 10-[6-CARBOXY-3-(6-CARBOXY-3,4,5-TRIHYDROXY-OXAN-2-YL)OXY-4,5-DIHYDROXY-OXAN-2-YL]OXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-3,4,5,6,6A,7,8,8A,10,11,12,14B-DODECAHYDRO-1H-PICENE-2-CARBOXYLATE
CAS:53956-04-0
MF:C42H65NO16
MW:839.97
EINECS:258-887-7
Product Categories:API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Biochemistry;Disaccharides;Glycosides;Natural Plant Extract;The group of Liquorice;Herb extract;Inhibitors;Pyridines;Organics;Sugars
Mol File:53956-04-0.mol
Glycyrrhizic acid ammonium salt Structure
Glycyrrhizic acid ammonium salt Chemical Properties
Melting point >200°C (dec.)
Boiling point 768.56°C (rough estimate)
density 1.1846 (rough estimate)
refractive index 49 ° (C=1.5, EtOH)
FEMA 2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
storage temp. 2-8°C
solubility Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides.
form Powder or Crystals
color Yellow to yellow-green
optical activity[α]20/D +48±4°, c = 1% in ethanol: water (1:1)
BRN 3897076
InChIKeyILRKKHJEINIICQ-YDYGGSECSA-N
CAS DataBase Reference53956-04-0
EPA Substance Registry System.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0)
Safety Information
RIDADR UN 3077 9 / PGIII
WGK Germany 2
RTECS LZ6500000
3-10
HS Code 29389090
Glycyrrhizic acid ammonium salt Usage And Synthesis
Description§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.
Chemical PropertiesLicorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation, followed by neutral- ization with dilute ammonia Monoammonium glycyrrhizinate (C42H62O16NH45H2O) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.
Chemical Propertieswhite to slightly yellow powder
UsesAmmonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl ammatory drugs with which Ammonium Glycyrrhizinate is associated.
Usesanti-cancer agent
Usespharmaceutical excipient, GRAS, sweetener
UsesGlycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.
General Description
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Anticancer ResearchGlycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.
Safety ProfileModerately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3.
Purification MethodsCrystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]
Glycyrrhizic acid ammonium salt Preparation Products And Raw materials
Raw materialsAmmonium hydroxide-->LACQUER THINNER-->Glycyrrhizic acid-->DGL
Preparation ProductsAmmonium Glycyrrhizinate
Tag:Glycyrrhizic acid ammonium salt(53956-04-0) Related Product Information
5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione DGL Sodium hyaluronate Glycyrrhizic acid Diammonium glycyrrhizinate BETA MAX? Ammonium Glycyrrhizinate GLYCYRRHIZIC ACID AMMONIUM SALT TRIHYDRATE GLYCYRRHIZIC ACID, MONOAMMONIUM SALT HYDRATE, CA. 75 Ammonium hydroxide Ammonium nitrate AMMONIUM Ammonium sulfate Glycyrrhizic acid ammonium salt Ammonium acetate Ammonium chloride GLYCYRRHIZIC ACID, AMMONIUM SALT, TRIHYDRATE(RG)