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Acemetacin

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Products Intro: Product Name:53164-05-9
CAS:53164-05-9
Purity:0.99 Package:25KG,5KG;1KG;500G
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CAS:53164-05-9
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Products Intro: Product Name:acemetacin
CAS:53164-05-9
Purity:0.99 Package:5KG;1KG Remarks:C21H18ClNO6
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Products Intro: Product Name:Acemetacin
CAS:53164-05-9
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg

Acemetacin manufacturers

  • acemetacin
  • $13.00 / Kg/Bag
  • 2022-01-22
  • CAS:53164-05-9
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  • CAS:53164-05-9
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  • 2021-12-01
  • CAS:53164-05-9
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Acemetacin Basic information
Product Name:Acemetacin
Synonyms:(1-(p-chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure;AURORA KA-6229;ACEMETACIN;[1-(4-CHLORO-BENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-ACETIC ACID CARBOXYMETHYL ESTER;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Carboxymethyl Ester;Emflex;Solart;1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetic aci carboxymethyl ((1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid (1-(p-chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetic acid carboxymethyl 2-(2-(1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid acemetacin acemetacinum acemix
CAS:53164-05-9
MF:C21H18ClNO6
MW:415.82
EINECS:258-403-4
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;API;EMFLEX
Mol File:53164-05-9.mol
Acemetacin Structure
Acemetacin Chemical Properties
Melting point 151.5°C
Boiling point 565.5±50.0 °C(Predicted)
density 1.2387 (rough estimate)
refractive index 1.6000 (estimate)
RTECS NL3521400
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Practically insoluble in water, soluble in acetone, slightly soluble in anhydrous ethanol.
form neat
pka2.60±0.10(Predicted)
color Very fine, pale-yellow crystals from pet eth
Merck 14,27
CAS DataBase Reference53164-05-9(CAS DataBase Reference)
Safety Information
Hazard Codes T+
Risk Statements 26/27/28
Safety Statements 22-25-36/37/39-45-24/25
RIDADR UN 2811
WGK Germany 3
HazardClass 6.1(a)
PackingGroup II
HS Code 29339900
ToxicityLD50 in male, female mice, male, female rats (mg/kg): 55.5, 18.42, 24.2, 30.1 orally; 34.1, 51.1, 38.1, 28.3 i.v. (Jacobi, Dell)
MSDS Information
ProviderLanguage
Acemetacin English
Acemetacin Usage And Synthesis
Chemical PropertiesLight Yellow Solid
OriginatorRantudil ,Bayer ,W. Germany ,1980
UsesA potent inhibitor of COX-2 found to have anti-tumor activity in the colon
UsesCyclo-oxygenase inhibitor; analgesic; anti-inflammatory.
DefinitionChEBI: A carboxylic ester that is the carboxymethyl ester of indometacin. A non-steroidal anti-inflammatory drug, it is used in the treatment of rheumatoid arthritis, osteoarthritis, and low back pain, as well as for postoperative pain and inflammation. Its activ ty is due to both acemetacin and its major metabolite, indometacin.
Manufacturing Process25.4 g (0.050 mol) of [1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3- indoleacetoxy]-benzyl acetate were dissolved in 400 ml of glacial acetic acid and hydrogenated on 2.0 g of palladium carbon at room temperature. After the absorption of hydrogen had finished (1 hour), the catalyst was filtered off, the filtrate was concentrated by evaporation under vacuum and the compound was caused to crystallize by adding petroleum ether. The compound melted at 149.5-150.5°C (determined on the micro-Kofler bench); the yield was 19.4 g which corresponds to 93% of the theoretical yield.
The starting material for the above step may be prepared as follows: 5 g (0.016 mol) of N1-(p-methoxyphenyl)-p-chlorobenzhydrazide hydrochloride and 4.75 g (0.018 mol) of benzyl levulinoyloxyacetate were heated in 25 ml of glacial acetic acid for 3 hours at 80°C. The solvent was then evaporated off under vacuum. The residue was taken up in chloroform and the solution was washed neutral by shaking with sodium bicarbonate solution and thereafter with water. After drying the chloroform solution, this was subjected to chromatography on aluminium oxide, the eluate was concentrated by evaporation and the viscous oil remaining as residue was crystallized by adding ether. The compound melted at 94-95°C. The yield was 4.1 g which corresponds to 50.7% of the theoretical yield.
Therapeutic FunctionAntiinflammatory
Safety ProfilePoison by ingestion, subcutaneous,intraperitoneal, intravenous, and intramuscular routes. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits toxic fumesof Cl?? and NOx. An anti-inflammatory agent.
Tag:Acemetacin(53164-05-9) Related Product Information
Delmetacin Indometacin 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID 2-METHYLINDOLE-3-ACETIC ACID 5-METHOXY-1-METHYL-1H-INDOLE 1-METHYLINDOLE-3-ACETIC ACID ETHYL ESTER 1-Ethyl-5-methoxyindole 5-HYDROXYINDOLE-3-ACETIC ACID 5-METHOXY-2-METHYLINDOLE 5-METHOXYTRYPTOPHOL 5-HYDROXYTRYPTOPHOL 3-METHYL-INDOLE-1-CARBALDEHYDE 1-Acetyl-5-methoxyindole Acemetacin 4-Methoxyphenylacetic acid Methoxy Ascoric Acid Ethyl 2-(Chlorosulfonyl)acetate