ChemicalBook > Product Catalog >API >Nervous system drugs >Antipsychotics >Chlorpromazine hydrochloride

Chlorpromazine hydrochloride

Chlorpromazine hydrochloride Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Chlorpromazine hydrochloride
CAS:69-09-0
Purity:99% Package:319/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Chlorpromazine hydrochloride
CAS:69-09-0
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:69-09-0
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Chlorpromazine hydrochloride
CAS:69-09-0
Company Name: PI & PI BIOTECH INC.
Tel: 020-81716320
Email: Sales@pipitech.com
Products Intro: Product Name:Chlorpromazine hydrochloride
CAS:69-09-0
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine hydrochloride

Lastest Price from Chlorpromazine hydrochloride manufacturers

Chlorpromazine hydrochloride Basic information
Product Name:Chlorpromazine hydrochloride
Synonyms:thorazinehydrochloride;Chlorpromazine hydrochloride CP2000,BP93;CHLORPOMAZINE HCL;CHLORPROMAZINE HYDROCHLORIDE USP;CHLOROPROMAZINE HYDROCHLORIDE VETRANAL, 250 MG;Hebanil. Klorpromex, 2-Chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine, HCl;10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, monohydrochloride;0-(3-dimethylaminopropyl)-2-chlorophenothiazine monohydrochloride
CAS:69-09-0
MF:C17H20Cl2N2S
MW:355.33
EINECS:200-701-3
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Sulfur & Selenium Compounds;API;Sonazine;-
Mol File:69-09-0.mol
Chlorpromazine hydrochloride Structure
Chlorpromazine hydrochloride Chemical Properties
Melting point 192-196°C
density 1.2221 (estimate)
Fp 9℃
storage temp. -20°C Freezer
solubility Very soluble in water, freely soluble in ethanol (96 per cent). It decomposes on exposure to air and light.
form Powder/Solution
color White to off-white or clear colorless
PHpH (50g/L, 25℃) : 4.0~5.0
Water Solubility >=10 g/100 mL at 24 ºC
Merck 14,2185
BRN 3779989
Stability:Stable. Combustible. Incompatible with strong oxidizing agents. Air and light sesnsitive.
CAS DataBase Reference69-09-0(CAS DataBase Reference)
EPA Substance Registry System10H-Phenothiazine- 10-propanamine, 2-chloro-N,N-dimethyl-, monohydrochloride(69-09-0)
Safety Information
Hazard Codes T+,T,F
Risk Statements 25-26-39/23/24/25-23/24/25-11
Safety Statements 28-36/37-45-16
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS SO1750000
3-10-21
TSCA Yes
HazardClass 6.1(b)
PackingGroup III
HS Code 29173980
ToxicityLD50 orally in rats: 225 mg/kg (Goldenthal)
MSDS Information
ProviderLanguage
Largactil English
SigmaAldrich English
Chlorpromazine hydrochloride Usage And Synthesis
Chemical PropertiesCrystalline Solid
UsesAntiemetic;Dopamine antagonist
UsesUsed as an Antiemetic, Antipsychotic
DefinitionChEBI: The hydrochloride salt of chlorpromazine.
Brand nameThorazine (GlaxoSmithKline).
General DescriptionWhite or creamy-white odorless crystalline powder with very bitter taste. pH (5% aqueous solution) 4.0-5.5. pH (10% aqueous solution) 4-5.
General DescriptionChlorpromazinehydrochloride, 2-chloro-10-[3-(dimethylamino)propyl]phenothiazine monohydrochloride (Thorazine), was the first phenothiazinecompound introduced into therapy. It is still usefulas an antipsychotic. Other uses are in nausea, vomiting, andhiccough. Oral doses of chlorpromazine and thioridazinehave systemic availability of 25% to 35% because of significantfirst-pass metabolism. Chlorpromazine and other phenothiazinesare metabolized extensively by CYP2D6. In contrast, bioavailability of chlorpromazine may beincreased up to 10-fold with injections, but the clinical doseusually is decreased by only threefold to fourfold.Chlorpromazine may weakly induce its own hepatic metabolism,because its concentration in blood is lower after severalweeks of treatment at the same dosage. Alterations of GImotility also may contribute. The drug has significant sedativeand hypotensive properties, possibly reflecting centralhistaminergic and peripheral α1-noradrenergic blockingactivity, respectively. Effects of peripheral anticholinergic activityare common. As with the other phenothiazines, the effectsof other CNS-depressant drugs, such as sedatives andanesthetics, can be potentiated.
Air & Water ReactionsDecomposes on exposure to air and light. becoming yellow, pink and, finally, violet. Water soluble.
Reactivity ProfileChlorpromazine hydrochloride is incompatible in aqueous solution with sodium salts of barbiturates and other alkaline solutions. Solutions may be stabilized by addition of antioxidants and storing under nitrogen.
Fire HazardFlash point data for Chlorpromazine hydrochloride are not available; however, Chlorpromazine hydrochloride is probably combustible.
Safety ProfilePoison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. An experimentalteratogen. Experimental reproductive effects. An anti-emetic and antipsychotic drug. Human systemic effects: anorexia (human), excitement, gastrointestinal changes, irritability, pulse rate increase, respiratory stimulation, rigidity, somnolence, sweating. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and SOx.
Chlorpromazine hydrochloride Preparation Products And Raw materials
Raw materialsDimethylamine-->1-Bromo-3-chloropropane-->2-Chlorophenothiazine
Tag:Chlorpromazine hydrochloride(69-09-0) Related Product Information
DIPHENYLAMINE HYDROCHLORIDE 2-Amino-4-chlorodiphenylsulfide 5-CHLORO-2-MERCAPTOANILINE HYDROCHLORIDE 3-CHLORO-N,N-DIMETHYLANILINE 3-CHLORO-N-ETHYLBENZENAMINE HYDROCHLORIDE PROCHLORPERAZINE 2 HCL (D3) N-(3-AMINOPROPYL)-N-METHYLANILINE 2-Chlorophenothiazine 4-CHLOROTHIOANISOLE Chlorpromazine hydrochloride Phenothiazine CHLORPROMAZINE Topotecan hydrochloride (-)-2-[METHYLAMINO]-1-PHENYLPROPANE Diisopropylamine D/L-AMPHETAMINE HYDROCHLORIDE Chlorpromazine Difluorochloromethane