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| | TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Basic information |
| Product Name: | TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- | | Synonyms: | OH-PEG3-CH2CH2COOtBu;OH-PEG3-TBA;tert-Butyl 3-(2-(2-(2-hydroxyethoxy);TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-;HO-PEG3-tBu;HO-PEG3-CH2CH2COOtBu;3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester;tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate >=97.0% (GC) | | CAS: | 186020-66-6 | | MF: | C13H26O6 | | MW: | 278.34 | | EINECS: | | | Product Categories: | peg | | Mol File: | 186020-66-6.mol |  |
| | TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Chemical Properties |
| Boiling point | 365.8±27.0 °C(Predicted) | | density | 1.052 g/mL at 20 °C (lit.) | | refractive index | n20/D 1.446 | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in DMSO | | form | clear liquid | | pka | 14.36±0.10(Predicted) | | color | Colorless to Light yellow to Light orange | | BRN | 7638988 | | CAS DataBase Reference | 186020-66-6 |
| WGK Germany | 3 | | F | 10 | | HS Code | 2918999090 |
| | TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Usage And Synthesis |
| Description | Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Biological Activity | Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. . | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target | | Non-cleavable < span> | PEGs | Alkyl/ether | |
| | TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Preparation Products And Raw materials |
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