| Company Name: |
Artis Biotech Co. Ltd.
|
| Tel: |
19138486554 18582380095 |
| Email: |
sales@artisbio.com |
| Products Intro: |
Product Name:Dofetilide D4
CAS:1189700-56-8
Purity:98% HPLC Package:5mg 20mg 50mg 100mg 200mg 1g
|
| Company Name: |
Clearsynth Canada Inc.
|
| Tel: |
+1.415.685.4395 |
| Email: |
enquiry@clearsynth.com |
| Products Intro: |
Product Name:Dofetilide D4
Package:10mg
|
| Company Name: |
Shenzhen SUNGENING Bio-Medical Co., Ltd.
|
| Tel: |
0755-28967200 13631290199 |
| Email: |
wxf@sungening.com |
| Products Intro: |
Product Name:Dofetilide D4
Purity:99% HPLC or More Package:10MG;25MG;50MG;100MG
|
|
| | DOFETILIDE-D4 Basic information |
| | DOFETILIDE-D4 Chemical Properties |
| Melting point | 130-1350C | | storage temp. | -20°C Freezer | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | color | White | | CAS DataBase Reference | 1189700-56-8 |
| | DOFETILIDE-D4 Usage And Synthesis |
| Description | Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg. Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm. | | Chemical Properties | White Crystalline Solid | | Uses | Potassium channel blocker. | | Uses | Dofetilide-d4 is intended for use as an internal standard for the quantification of Dofitilide by GC- or LC-mass spectrometry. |
| | DOFETILIDE-D4 Preparation Products And Raw materials |
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