| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:HUMAN TGF-BETA3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
ACROBiosystems
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| Tel: |
18514007688 |
| Email: |
jiaxin.zhao@acrobiosystems.com |
| Products Intro: |
Product Name:TGF-beta 3
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| Company Name: |
United States Biological
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| Tel: |
1-800-520-3011 |
| Email: |
sales@advtechind.com |
| Products Intro: |
Product Name:Transforming Growth factor, beta 3
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| | HUMAN TGF-BETA3 Basic information |
| Product Name: | HUMAN TGF-BETA3 | | Synonyms: | HUMAN TRANSFORMING GROWTH FACTOR BETA 3;HUMAN TGF-BETA3;HUMAN TGF-B3;TGF-BETA3;TGF-BETA3, HUMAN;RECOMBINANT HUMAN TGF-B3;TRANSFORMING GROWTH FACTOR-BETA3;TRANSFORMING GROWTH FACTOR-BETA3, HUMAN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![HUMAN TGF-BETA3 Structure]() |
| | HUMAN TGF-BETA3 Chemical Properties |
| storage temp. | -20°C | | form | powder | | color | white |
| | HUMAN TGF-BETA3 Usage And Synthesis |
| Uses | TGF-β3 (transforming growth factor β 3) human has been used in the media for the chondrogenic differentiation of the stromal cells. It has been used in the culture medium to allow attachment of primary human dermal fibroblasts to the scaffolds. | | General Description | The gene TGF-β3 (transforming growth factor β 3) is mapped to human chromosome 14q24.3. The three mammalian isoforms of TGF-β, TGF-β1, β2, β3 elicit similar biological responses. TGF-β proteins are made as precursor molecules which are cut to generate a mature carboxy-terminal region of 110-140 amino acids. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. Recombinant TGF-β3 is a 25.0kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. | | Biochem/physiol Actions | The three mammalian isoforms of TGF-β (transforming growth factor β), TGF-β1, β2, β3, are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. TGF-β3 is the predominant TGF-β in the testis and controls the blood-testis barrier activity. Polymorphisms in this gene might be associated with male infertility. Heterozygous mutation in the gene at position Arg300 might be associated with increased TGF-β signaling, leading to a disorder with phenotypic overlap with Marfan syndrome and Loeys-Dietz syndrome. TGF-β3 is involved in the mesenchymal stem cells (MSCs)-mediated inhibition of fibroblast proliferation and decreases skin fibrosis. |
| | HUMAN TGF-BETA3 Preparation Products And Raw materials |
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