5-NITROSO-8-HYDROXYQUINOLINE manufacturers
- 5-nitrosoquinolin-8-ol
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- $1.00 / 1KG
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2020-02-17
- CAS:3565-26-2
- Min. Order: 1KG
- Purity: 98% HPLC
- Supply Ability: 10 tons
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| | 5-NITROSO-8-HYDROXYQUINOLINE Basic information |
| Product Name: | 5-NITROSO-8-HYDROXYQUINOLINE | | Synonyms: | 8-HYDROXY-5-NITROSOQUINOLINE;NSC 3852;5-Nitroso-8-cinnolinol;5-nitroso-8-quinolino;8-Quinolinol, 5-nitroso-;Hydron III;hydroniii;RMH-79 | | CAS: | 3565-26-2 | | MF: | C9H6N2O2 | | MW: | 174.16 | | EINECS: | 222-650-6 | | Product Categories: | | | Mol File: | 3565-26-2.mol |  |
| | 5-NITROSO-8-HYDROXYQUINOLINE Chemical Properties |
| Melting point | 245 °C | | Boiling point | 305.12°C (rough estimate) | | density | 1.40 | | refractive index | 1.5651 (estimate) | | storage temp. | Store at RT | | solubility | insoluble in EtOH; insoluble in H2O; ≥7.35 mg/mL in DMSO | | form | solid | | color | Needles from EtOH | | CAS DataBase Reference | 3565-26-2(CAS DataBase Reference) | | EPA Substance Registry System | 8-Quinolinol, 5-nitroso- (3565-26-2) |
| Hazard Codes | Xn | | Risk Statements | 5-40-20/21/22 | | Safety Statements | 36/37 | | Toxicity | mmo-sat 1 mmol/plate MUREAV 164,263,86 |
| Provider | Language |
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ACROS
| English |
| | 5-NITROSO-8-HYDROXYQUINOLINE Usage And Synthesis |
| Chemical Properties | slightly yellow to yellow-green powder | | Uses | 5-NITROSO-8-HYDROXYQUINOLINE is shown to have cell differentiation and antiproliferative activity in human breast cancer cells in tissue culture and antitumor activity in mice bearing P388 and L1210 leukemic cells. | | Definition | ChEBI: 5-nitroso-8-quinolinol is a hydroxyquinoline. | | Biological Activity | Histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo . | | Safety Profile | Poison by intravenous and intraperitoneal routes. Many nitroso compounds are carcinogens. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. | | storage | Room temperature | | references | [1]. martirosyan a, leonard s, shi x, et al. actions of a histone deacetylase inhibitor nsc3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in mcf-7 human mammary tumor cells. j pharmacol exp ther, 2006, 317(2): 546-552.
[2]. strobl js, seibert cw, li y, et al. inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active antiproliferative and tumor cell differentiation agent. j parasitol, 2009, 95(1): 215-223. |
| | 5-NITROSO-8-HYDROXYQUINOLINE Preparation Products And Raw materials |
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