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Penicillin V potassium salt

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Products Intro: Product Name:Penicillin V Potassium
CAS:132-98-9
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Products Intro: Product Name:Phenoxymethylpenicillin Potassium
CAS:132-98-9
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CAS:132-98-9
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CAS:132-98-9
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CAS:132-98-9
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Penicillin V potassium salt manufacturers

  • Penicillin V potassium
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  • $150.00 / 1ASSAYS
  • 2023-06-26
  • CAS:132-98-9
  • Min. Order: 10g
  • Purity: >99%
  • Supply Ability: 500kg/month
Penicillin V potassium salt Basic information
Product Name:Penicillin V potassium salt
Synonyms:Penicillin V potassium salt, Phenoxymethylpenicillinic acid potassium salt;PHENOXYMETHYLPENICILLINIC ACID POTASSIUM SALT;PHENOXYMETHYLPENICILLIN K+ SALT;PHENOXYMETHYL PENICILLIN POTASSIUM SALT;PENICILLIN VK;PENICILLIN V POTASSIUM SALT;PENICILLINE V POTASSIUM SALT;4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-7-oxo-6-((ph
CAS:132-98-9
MF:C16H17KN2O5S
MW:388.48
EINECS:205-086-5
Product Categories:Inhibitors;BEEPEN-VK;antibiotic;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Peptide Synthesis/Antibiotics
Mol File:132-98-9.mol
Penicillin V potassium salt Structure
Penicillin V potassium salt Chemical Properties
Melting point 197-202°C
alpha D25 +223° (c = 0.2)
density 1.40
storage temp. Inert atmosphere,2-8°C
solubility Freely soluble in water, practically insoluble in ethanol (96 per cent).
color Sol in water
Water Solubility Soluble in water, dimethyl sulfoxide, and methanol.
BRN 3899451
BCS Class1 (CLogP), 3 (LogP)
Stability:Hygroscopic
InChIKeyHCTVWSOKIJULET-LQDWTQKMSA-M
CAS DataBase Reference132-98-9(CAS DataBase Reference)
EPA Substance Registry SystemPenicillin V Potassium (132-98-9)
Safety Information
Hazard Codes Xn
Risk Statements 22-42/43
Safety Statements 22-26-36/37-45
WGK Germany 3
RTECS XH9275000
TSCA Yes
HS Code 29411099
Hazardous Substances Data132-98-9(Hazardous Substances Data)
ToxicityLD50 orally in rats: >1040 mg/kg (Goldenthal)
MSDS Information
ProviderLanguage
Penicillin V potassium salt English
Penicillin V potassium salt Usage And Synthesis
Chemical PropertiesCrystalline Solid
OriginatorOracilline ,Theraplix ,France ,1954
UsesPenicillin V Potassium bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication. It inhibits biosynthesis of cell-wall mucopeptide. It is used to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
UsesPenicillin antibacterial.
DefinitionChEBI: Phenoxymethylpenicillin potassium is an organic potassium salt. It contains a phenoxymethylpenicillin(1-).
ApplicationPhenoxymethylpenicillin potassium was first obtained at Lilly Research Laboratories in 1948, following the addition of phenoxyacetic acid to a culture of Penicillium chrysogenum. Its industrial-scale production was established in 1953. Its usefulness as an orally active penicillin was suggested by Spitzy et al. in 1955. It is less hygroscopic and much more stable against gastric acid than benzylpenicillin, and it has been used orally for therapy of infections caused by Streptococcus, Staphylococcus, and other gram-positive bacteria as well as Neisseria and Leptospira.
Manufacturing ProcessThe following description is taken from US Patent 2,941,995. A solution of phenoxyacetyl chloride (360 mg) in dry acetone (5 ml) was added dropwise during 10 minutes to a stirred solution of 6-aminopenicillanic acid (450 mg, approximately 75% pure) in 3% aqueous bicarbonate (18 ml), and acetone (12 ml). When addition was complete the mixture was stirred at room temperature for 30 minutes and then extracted with ether (30 ml in 3 portions), only the aqueous phase being retained. This aqueous solution was covered with butanol (5 ml) and adjusted to pH 2 by the addition of N hydrochloric acid. After separating the layers, the aqueous phase was extracted with two 2.5 ml portions of butanol, adjusting to pH 2 each time. The combined butanol solutions (which at this stage contained the free penicillanic acid) were washed with water (3 x 2 ml) and then shaken with water (10 ml) to which sufficient 3% sodium bicarbonate solution was added to bring the aqueous phase to pH 7. The butanol solution was further extracted with two 5 ml portions of water to each of which was added enough bicarbonate solution to produce an aqueous phase of pH 7. The combined aqueous solutions were washed with ether (20 ml) and then evaporated at low temperature and pressure to leave the crude sodium salt of phenoxymethyl penicillin which, after drying in a vacuum desiccator, was obtained as a slightly hygroscopic powder (591 mg).
Brand nameV-Cillin(Lilly).
Therapeutic FunctionAntibacterial
General DescriptionOdorless white crystalline powder. Slightly bitter taste. pH (0.5% aqueous solution) 5 to 7.5.
Air & Water ReactionsWater soluble.
Reactivity ProfilePenicillin V potassium salt is the potassium salt of penicillin v. Penicillin V potassium salt is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents. Penicillin V potassium salt is also incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides. Other incompatibilities include reducing agents, alcohols, other hydroxy compounds, self-emulsifying stearyl alcohol, emulsifying wax, lanolin, crude cholinesterated bases, glycol, sugars, amines, aminacrine hydrochloride, ephedrine, procaine, rubber tubing, thiamine hydrochloride, zinc oxide, oxidized cellulose, iodine, iodides, thiols, chlorocresol and resorcinol. Penicillin V potassium salt may also be incompatible with naphthalene oils and vitamin B.
Fire HazardFlash point data for Penicillin V potassium salt are not available; however, Penicillin V potassium salt is probably combustible.
Safety ProfileModerately toxic by ingestion, intramuscular, intraperitoneal, and intravenous routes. Human mutation data reported. Questionable carcinogen with no experimental evidence. When heated to decomposition it emits very toxic fumes of NOx, K2O, and SOx. Used
Penicillin V potassium salt Preparation Products And Raw materials
Raw materials6-Aminopenicillanic acid-->Phenoxyacetyl chloride
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