- Methoxyacetyl chloride
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- $8.90 / 1KG
-
2025-06-24
- CAS:38870-89-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- Methoxyacetyl chloride
-
- $1.00 / 1KG
-
2025-05-19
- CAS:38870-89-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200000KG
- Methoxyacetyl chloride
-
- $1.00 / 1kg
-
2019-07-06
- CAS:38870-89-2
- Min. Order: 1kg
- Purity: 95%-99%
- Supply Ability: as request
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| | Methoxyacetyl chloride Basic information |
| Product Name: | Methoxyacetyl chloride | | Synonyms: | METHOXYACETYL CHLORIDE, STAB.;Methoxyacetyl chloride, stabilized, ca. 95%;MEYHOXY ACETYL CHLORIDE;Methoxyacetyl chloride, GC 95%;Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide;Methoxyacetyl Chloride [Chloromethylating Reagent];Methoxyacetyl chloride, ca. 95%, stabilized;Methoxyacetyl chloride, stabilized | | CAS: | 38870-89-2 | | MF: | C3H5ClO2 | | MW: | 108.52 | | EINECS: | 254-169-2 | | Product Categories: | Chlorination;Halogenation;Synthetic Organic Chemistry | | Mol File: | 38870-89-2.mol |  |
| | Methoxyacetyl chloride Chemical Properties |
| Melting point | <-40°C | | Boiling point | 112-113 °C (lit.) | | density | 1.187 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.419(lit.) | | Fp | 84 °F | | storage temp. | 2-8°C | | solubility | Miscible with acetone, ether, carbon tetrachloride and chloroform. | | form | Liquid | | color | Clear colorless to yellow | | Water Solubility | reacts | | Sensitive | Moisture Sensitive | | BRN | 1740244 | | Stability: | Moisture sensitive | | InChIKey | JJKWHOSQTYYFAE-UHFFFAOYSA-N | | CAS DataBase Reference | 38870-89-2(CAS DataBase Reference) | | NIST Chemistry Reference | Methoxyacetyl chloride(38870-89-2) | | EPA Substance Registry System | Acetyl chloride, methoxy- (38870-89-2) |
| | Methoxyacetyl chloride Usage And Synthesis |
| Description | Methoxyacetyl chloride is a acylating reagent; precursor to methoxyketene; in combination with Lewis acids is a reagent for aromatic
chloromethylation. | | Chemical Properties | clear colorless to yellow liquid | | Uses | Methoxyacetyl chloride is used as an intermediate for active pharmaceutical ingredients and dyes. Further, it acts as a precursor for the synthesis of agrochemicals. | | Synthesis | Step 1: To a solution of methoxyacetic acid (20 mL, 0.26 mol) in dichloromethane (170 mL) was added dropwise oxalyl chloride (30 mL, 0.34 mol) and a catalytic amount of DMF (a few drops) at 0 °C. The reaction mixture was stirred at room temperature overnight and the solvent was subsequently removed by rotary evaporator. The residue was distilled under reduced pressure to afford methoxyacetyl chloride (54b, 25.4 g, 90% yield). | | References | [1] Patent: WO2008/33562, 2008, A2. Location in patent: Page/Page column 74
[2] Patent: US2009/76005, 2009, A1. Location in patent: Page/Page column 36
[3] Journal of Organic Chemistry, 2003, vol. 68, # 17, p. 6832 - 6835
[4] European Journal of Organic Chemistry, 2005, # 12, p. 2459 - 2467
[5] Tetrahedron, 2018, vol. 74, # 27, p. 3663 - 3670 |
| | Methoxyacetyl chloride Preparation Products And Raw materials |
| Raw materials | N,N-Dimethylformamide-->Thionyl chloride-->Chloroacetic acid-->Methoxyacetic acid-->Dichloromethane-->Oxalyl chloride | | Preparation Products | Metalaxyl-->Oxadixyl-->ISOCYANATO(METHOXY)METHANE-->methoxyacetic anhydride-->carbon monoxide-->2-(Methoxymethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol-->Benzoic acid, 2-[(Methoxyacetyl)aMino]-, Methyl ester-->2-[3-(Methoxymethyl)-1H-1,2,4-triazol-5-yl]pyridine-->N-(4-bromophenyl)-2-methoxyacetamide-->3-CHLOROMETHYL-4-METHOXY-BENZOIC ACID METHYL ESTER-->5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride |
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