- Hymexazol
-
- $10.00 / 1ASSAYS
-
2025-11-15
- CAS:10004-44-1
- Min. Order: 1ASSAYS
- Purity: 99%
- Supply Ability: 1 ton
- Hymexazol
-
- $120.00 / 1kg
-
2025-11-14
- CAS:10004-44-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000
- Hymexazol
-
- $10.00 / 1KG
-
2025-11-14
- CAS:10004-44-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
|
| | Hymexazol Basic information |
| | Hymexazol Chemical Properties |
| Melting point | 80°C | | Boiling point | 185.54°C (rough estimate) | | density | 1.2992 (rough estimate) | | vapor pressure | 0.182 Pa (25 °C) | | refractive index | 1.4170 (estimate) | | storage temp. | 2-8°C | | solubility | Soluble in alcohol, acetone, THF, chloroform | | form | Powder | | pka | 5.91 (weak acid) | | Water Solubility | 65,100 mg l-1 (20 °C) | | color | White to Orange | | Sensitive | Light Sensitive | | Merck | 14,4856 | | InChIKey | KGVPNLBXJKTABS-UHFFFAOYSA-N | | CAS DataBase Reference | 10004-44-1(CAS DataBase Reference) | | EPA Substance Registry System | Hymexazol (10004-44-1) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-41-52/53 | | Safety Statements | 26-39-61 | | WGK Germany | 3 | | RTECS | NY2932000 | | HS Code | 29349990 | | Toxicity | LD50 in male, female mice, rats (mg/kg): 2148, 1968, 4678, 3909 orally; 1297, 1167, 1924, 1884 s.c.; 445, 514, >1000, >1000 i.v.; in rats, rabbits (mg/kg): >10000, >2000 dermally (Nakamura, 1978) |
| | Hymexazol Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | Agricultural fungicide and plant growth regulator. | | Uses | Pesticide. | | Uses | Hymexazol is used to control soil-borne diseases caused by
Fusarium, Aphanomyces, Pythium, Corficium and Typhula spp. in rice, sugar
beet, fodder beet, vegetables, cucurbits, ornamentals, carnations and
forest tree seedlings. It is also used as a seed dressing and stimulates some
plant growth. | | Definition | ChEBI: A member of the class of isoxazoles carrying hydroxy and methyl substituents at positions 3 and 5 respectively. It is used worldwide as a systemic soil and seed fungicide for the control of diseases caused by Fusarium, Aphanomyces
Pythium, and Corticium spp. in rice, sugarbeet, fodderbeet, vegetables, cucurbits, and ornamentals. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 48, p. 4307, 1983 DOI: 10.1021/jo00171a030 | | Mechanism of action |
Hymexazol works by inhibiting RNA synthesis in pathogenic fungi, disrupting their growth and reproduction.
| | Metabolic pathway | Degradation of hymexazol in soil gave acetoacetamide and the product
of rearrangement, 5-methyl-2(3H)-oxazolone.H owever, in plants the fungicide
was principally converted into its O- and N-glucoside conjugates in
the roots and shoots. The two main metabolites of hymexazol found in the
urine of rats were the O-glucuronide and sulfate conjugates. | | Degradation | Hymexazol is stable under alkaline conditions and relatively stable in
acidic conditions. It is stable to sunlight and heat (PM). It should be noted
that the parent molecule is tautomeric. Hymexazol is highly volatile and
will be lost by volatilisation unless it is covered or incorporated into soil.
The fungicide was completely biodegraded in natural water at 30 °C in
2 weeks and at 10-13 °C in 2 months (Rebenok and Kolesnikova, 1983).
Hymexazol is stable in sunlight but it is readily degraded by ultraviolet
light. Photolysis of an aqueous solution of the fungicide at 253.7 nm, using
a low pressure Hg lamp, afforded the oxazolinone (2) as the major product
and at least two unidentified minor components. The oxazolinone (2)
has been found in soil studies as described below and is a product of
rearrangement formed via an aziridinone intermediate as shown in
Scheme 1 (Nakagawa et al., 1974). |
| | Hymexazol Preparation Products And Raw materials |
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