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NS-398

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Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +8613288715578
Email: sales@hbmojin.com
Products Intro: Product Name:NS-398
CAS:123653-11-2
Purity:99% Package:25KG
Company Name: Hebei Yanxi Chemical Co., Ltd.
Tel: +8617531190177
Email: peter@yan-xi.com
Products Intro: Product Name:NS-398
CAS:123653-11-2
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Products Intro: Product Name:NS-398
CAS:123653-11-2
Purity:99% Package:1kg;50USD
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:NS-398
CAS:123653-11-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:NS-398
CAS:123653-11-2
Purity:0.99, AD68 Package:1g;1USD

NS-398 manufacturers

  • NS-398
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  • $50.00 / 1kg
  • 2024-04-12
  • CAS:123653-11-2
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 1000
  • NS-398
  • NS-398 pictures
  • $0.00 / 25KG
  • 2023-12-04
  • CAS:123653-11-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50000KG/month
  • NS-398
  • NS-398 pictures
  • $20.00 / 1kg
  • 2023-11-28
  • CAS:123653-11-2
  • Min. Order: 1kg
  • Purity: 0.99
  • Supply Ability: 10 tons
NS-398 Basic information
Product Name:NS-398
Synonyms:NS-398;N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]-METHANESULFONAMIDE;NS-398 98%;N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide;Taisho NS 398;CS-2231;NS-398 (NS 398;NS-398 - CAS 123653-11-2 - Calbiochem
CAS:123653-11-2
MF:C13H18N2O5S
MW:314.36
EINECS:
Product Categories:Signalling;Lipid signaling;NF-κB Signaling
Mol File:123653-11-2.mol
NS-398 Structure
NS-398 Chemical Properties
Melting point 124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point 490.6±55.0 °C(Predicted)
density 1.377±0.06 g/cm3(Predicted)
RTECS PB0473500
storage temp. Sealed in dry,Room Temperature
solubility DMSO: >5 mg/mL
form solid
pka6.33±0.10(Predicted)
color off-white
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 2935.90.9500
MSDS Information
ProviderLanguage
SigmaAldrich English
NS-398 Usage And Synthesis
DescriptionNS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC50 values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively.
UsesNS-398 is a selective Cox-2 inhibitor neuroprotective agent.
DefinitionChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Biological ActivitySelective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .
storageStore at RT
references[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46.
NS-398 Preparation Products And Raw materials
Preparation ProductsAcrylamide-->Glyoxal
Tag:NS-398(123653-11-2) Related Product Information
CALPHOSTIN C Trypsin inhibitor Potassium heptadecafluoro-1-octanesulfonate Pentasodium DTPA AG 18 AG 490 TYRPHOSTIN A25 Roscovitine Potassium clavulanate Ancymidol NS-398 3-ISOPROPOXYANILINE 4-NITRO-2-PROPOXY-PHENYLAMINE 4-NITRO METHANESULFONANILIDE 4-nitro-o-phenetidine N-(2-METHOXY-4-NITRO-PHENYL)-METHANESULFONAMIDE NS-398 (N-(2-Cyclohexyloxy-4-nitrophenyl) -Methanesulfonamide) Methanesulfonamide, N-(2-ethoxyphenyl)- (9CI)