- Metrizoic acid
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- $350.00 / 1KG
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2021-10-20
- CAS:1949-45-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 9000kg/per week
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| | Metrizoic acid Basic information |
| Product Name: | Metrizoic acid | | Synonyms: | METRIZOIC ACID;3-ACETAMIDO-5-(N-METHYLACETAMIDO)-2,4,6-TRIIODOBENZOIC ACID;3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo-benzoicaci;3-acetamido-2,4,6-triiodo-5-(n-methylacetamido)-benzoicaci;metrizoate;3-acetamido-2,4,6-triiodo-5-N-methylacetamidobenzoic acid;3-(Acetylamino)-5-[acetyl methyl-amino)2,4,6-triiodobenzoic acid;Metrizoic | | CAS: | 1949-45-7 | | MF: | C12H11I3N2O4 | | MW: | 627.94 | | EINECS: | 217-761-1 | | Product Categories: | Amines;Aromatics;Diagnostic;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 1949-45-7.mol |  |
| | Metrizoic acid Chemical Properties |
| | Metrizoic acid Usage And Synthesis |
| Originator | Isopaque,Winthrop,France,1973 | | Uses | Diagnosis aid (radiopaque medium). | | Definition | ChEBI: Metrizoic acid is a monocarboxylic acid. It has a role as a radioopaque medium. | | Manufacturing Process | 3,5-Diacetamido-2,4,6-triiodobenzoic acid (diatrizoic acid) (see Diatrizoate entry for synthesis) (10 g) is suspended in water (10 ml), 5 N potassium
hydroxide (4.3 equivalent) is added and the mixture cooled to about 15°C.
Dimethyl sulfate (0.5 equivalent) dissolved in an equal volume of acetone is
added drop by drop while stirring. After the reaction mixture has been stirred
for about 1 hour hydrochloric acid (1:1) is added, with stirring to pH about
0.5. The precipitate is filtered, washed and suspended moist in 4 parts of
water, concentrated ammonia is added to pH about 7 and the ammonium salt
solution is isomerized at 90°C to 100°C for about one-half hour whereafter
additional ammonia is added to pH about 9 followed by solid ammonium
chloride (about 10% weight/volume) and the solution stirred overnight and
the excess of 3,5-diacetamide-2,4,6-triiodobenzoic acid recovered as
ammonium salt on the filter. The filtrate is precipitated by means of
hydrochloric acid (1:1 ) at pH about 0.5 and the N-methyl-3,5-diacetamido-
2,4,6-triiodobenzoic acid collected on a filter, washed and dried. | | Therapeutic Function | Diagnostic aid (radiopaque medium) |
| | Metrizoic acid Preparation Products And Raw materials |
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