Phthalimide-PEG3-C2-OTs

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CAS:382162-12-1
Purity:98.00% Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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CAS:382162-12-1
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CAS:382162-12-1
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CAS:382162-12-1
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Products Intro: Product Name:Phthalimide-PEG3-C2-OTs
CAS:382162-12-1
Purity:98% HPLC
Phthalimide-PEG3-C2-OTs Basic information
Product Name:Phthalimide-PEG3-C2-OTs
Synonyms:Phthalimide-PEG3-C2-OTs;1H-Isoindole-1,3(2H)-dione, 2-[2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-
CAS:382162-12-1
MF:C23H27NO8S
MW:477.53
EINECS:
Product Categories:
Mol File:382162-12-1.mol
Phthalimide-PEG3-C2-OTs Structure
Phthalimide-PEG3-C2-OTs Chemical Properties
Boiling point 624.4±55.0 °C(Predicted)
density 1.300±0.06 g/cm3(Predicted)
pka-2.26±0.20(Predicted)
Safety Information
MSDS Information
Phthalimide-PEG3-C2-OTs Usage And Synthesis
UsesPhthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG3-C2-OTs can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Biological ActivityPhthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG3-C2-OTs can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50PEGs
References[1]. Stegmaier P, et al. Photoactive branched and linear surface architectures for functional and patterned immobilization of proteins and cells onto surfaces: a comparative study. Chemphyschem. 2009 Feb 2;10(2):357-69.
Phthalimide-PEG3-C2-OTs Preparation Products And Raw materials
Tag:Phthalimide-PEG3-C2-OTs(382162-12-1) Related Product Information

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