| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:Phthalimide-PEG3-C2-OTs
CAS:382162-12-1
Package:100mg;250mg;500mg Remarks: 试剂级
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:Phthalimide-PEG3-C2-OTs
CAS:382162-12-1
Purity:95% Package:100mg;250mg;1g Remarks:BD01416219
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| | Phthalimide-PEG3-C2-OTs Basic information |
| Product Name: | Phthalimide-PEG3-C2-OTs | | Synonyms: | Phthalimide-PEG3-C2-OTs;1H-Isoindole-1,3(2H)-dione, 2-[2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]- | | CAS: | 382162-12-1 | | MF: | C23H27NO8S | | MW: | 477.53 | | EINECS: | | | Product Categories: | | | Mol File: | 382162-12-1.mol |  |
| | Phthalimide-PEG3-C2-OTs Chemical Properties |
| Boiling point | 624.4±55.0 °C(Predicted) | | density | 1.300±0.06 g/cm3(Predicted) | | pka | -2.26±0.20(Predicted) |
| | Phthalimide-PEG3-C2-OTs Usage And Synthesis |
| Uses | Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG3-C2-OTs can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | Biological Activity | Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG3-C2-OTs can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. Stegmaier P, et al. Photoactive branched and linear surface architectures for functional and patterned immobilization of proteins and cells onto surfaces: a comparative study. Chemphyschem. 2009 Feb 2;10(2):357-69. |
| | Phthalimide-PEG3-C2-OTs Preparation Products And Raw materials |
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