| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:Cycrimine Hydrochloride
CAS:126-02-3
Purity:NULL Package:2.5g;250mg Remarks:NULL
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| Company Name: |
Guangzhou Juntang Technology Co., Ltd
|
| Tel: |
020-36607679 13502246435 |
| Email: |
sales@dmstandards.com |
| Products Intro: |
Product Name:Benzhexol Impurity 14（Cycrimine Hydrochloride）
CAS:126-02-3
Purity:95%+ Package:10mg，50mg，100mg，200mg
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| | cycrimine hydrochloride Basic information |
| Product Name: | cycrimine hydrochloride | | Synonyms: | cycrimine hydrochloride;1-Piperidinepropanol, .alpha.-cyclopentyl-.alpha.-phenyl-, hydrochloride;1-cyclopentyl-1-phenyl-3-piperidin-1-yl-propan-1-ol hydrochloride;1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol hydrochloride;1-cyclopentyl-1-phenyl-3-piperidino-propan-1-ol hydrochloride;CoMpound 8958;NSC 169452;Pagitane hydrochloride | | CAS: | 126-02-3 | | MF: | C19H29NO.ClH | | MW: | 0 | | EINECS: | 2047648 | | Product Categories: | | | Mol File: | 126-02-3.mol |  |
| | cycrimine hydrochloride Chemical Properties |
| Melting point | 239 - 241°C | | storage temp. | -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) | | form | Solid | | color | White |
| | cycrimine hydrochloride Usage And Synthesis |
| Originator | Pagitane,Lilly,US,1953 | | Uses | Cycrimine Hydrochloride is a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms. | | Definition | ChEBI: The hydrochloride salt of cycrimine. A central anticholinergic, it is used as its hydrochloride salt in the management and treatment of Parkinson's disease. | | Manufacturing Process | The manufacture of the cyclohexyl analog is as follows. Phenyl magnesium
bromide was prepared from 48.5 g (0.308 mol) of bromobenzene, 7 g (0.29
mol) of magnesium, and 125 ml of dry ether. To it was added at 5°C over a
period of ? hour 40 g (0.18 mol) of cyclohexyl β-(N-piperidyl)-ethyl ketone
(BP 115° to 117°C/1 mm) in 125 ml of dry ether. The mixture was allowed
slowly to come to room temperature, refluxed for one hour, and then poured
into ice containing 80 ml of concentrated hydrochloric acid. Ammonium chloride (100 g) and 200 ml of concentrated ammonium hydroxide were
added and the organic layer was separated. After drying and removing the
solvent, the residue was distilled under reduced pressure. The base distilled at
158° to 170°C (1 mm) and solidified. Upon recrystallization from methanol it
melted at 112° to 113°C. | | Brand name | Pagitane
(Lilly). | | Therapeutic Function | Muscle relaxant, Antiparkinsonian |
| | cycrimine hydrochloride Preparation Products And Raw materials |
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