| Company Name: |
Hangzhou Sage Chemical Co., Ltd.
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| Tel: |
+86057186818502 13588463833 |
| Email: |
info@sagechem.com |
| Products Intro: |
Product Name:Benzoic acid, 2-[[(diethylaMino)acetyl]aMino]-3-Methyl-, Methyl ester
CAS:3686-58-6
Purity:98% Package:1g;5g;100g;Bulk
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- tolycaine USP/EP/BP
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- $1.10 / 1g
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2021-07-27
- CAS:3686-58-6
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons min
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| | tolycaine Basic information |
| Product Name: | tolycaine | | Synonyms: | 2-[2-(Diethylamino)acetylamino]-m-toluic acid methyl ester;2-[[2-(diethylamino)acetyl]amino]-3-methyl-benzoic acid methyl ester;methyl 2-[[2-(diethylamino)acetyl]amino]-3-methylbenzoate;methyl 2-[2-(diethylamino)ethanoylamino]-3-methyl-benzoate;Methyl 2-(2-(diethylaMino)acetaMido)-3-Methylbenzoate;tolycaine;Benzoic acid, 2-[[(diethylaMino)acetyl]aMino]-3-Methyl-, Methyl ester;Benzoic acid, 2-[[2-(diethylamino)acetyl]amino]-3-methyl-, methyl ester | | CAS: | 3686-58-6 | | MF: | C15H22N2O3 | | MW: | 278.35 | | EINECS: | 222-976-9 | | Product Categories: | | | Mol File: | 3686-58-6.mol |  |
| | tolycaine Chemical Properties |
| Melting point | <25 °C | | Boiling point | bp5 190-192° | | density | 1.113±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 100 mg/mL (359.26 mM) | | pka | 13.61±0.70(Predicted) |
| | tolycaine Usage And Synthesis |
| Originator | Tolycaine
Hydrochloride,ZYF Pharm Chemical | | Definition | ChEBI: Tolycaine is an amidobenzoic acid. | | Manufacturing Process | A suspension of 40 g 2-amino-3-methylbenzoic acid methyl ester in 125 ml of
benzene was added 125 ml of saturated solution of sodium acetate and then
at 0-5°C was added 37 g chloracetylchloride. The mixture was stirred for 1
hour at room temperature. The mixture was filtered. The organic layer was
with 10% solution of potassium carbonate and dries under calcium chloride.
By distillation of the mixture was obtained 15 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester; melting point 86-87.5°C (crystallization from
a mixture acetic acid and ligroin); yield 21.8 g.
A mixture of 16 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl
ester and 10 g diethyl amine in benzene was refluxed for 5 hours. After
cooling the diethyl amine hydrochloride was deleted by filtration. The organic
layer was washed with 2 N hydrochloric acid. To the solution was added
potassium carbonate. The product was extracted with ether and distilled. | | Brand name | Tolycaine Hydrochloride is
JAN. | | Therapeutic Function | Local anesthetic |
| | tolycaine Preparation Products And Raw materials |
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