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| | NTRC 00660 Basic information |
| Product Name: | NTRC 00660 | | Synonyms: | NTRC 00660;NTRC 0066 0,NTRC 00660;Pyrimido[4,5-e]indolizine-7-carboxamide, N-(2,6-diethylphenyl)-5,6-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]- | | CAS: | 1817791-73-3 | | MF: | C33H39N7O2 | | MW: | 565.71 | | EINECS: | | | Product Categories: | | | Mol File: | 1817791-73-3.mol |  |
| | NTRC 00660 Chemical Properties |
| density | 1.27±0.1 g/cm3(Predicted) | | pka | 13?+-.0.70(Predicted) |
| | NTRC 00660 Usage And Synthesis |
| Description | NTRC-0066-0 is a a highly potent and selective small molecule inhibitor of TTK. In cell lines and in mice, NTRC 0066-0 inhibits the phosphorylation of a TTK substrate and induces chromosome missegregation. NTRC 0066-0 inhibits tumor growth in MDA-MB-231 xenografts as a single agent after oral application. The combination of NTRC 0066-0 with a therapeutic dose of docetaxel resulted in doubling of mouse survival and extended tumor remission, without toxicity. |
| | NTRC 00660 Preparation Products And Raw materials |
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