| Company Name: |
Nanchang Tianzhen Biotechnology Co., Ltd
|
| Tel: |
13173652190 |
| Email: |
pomy@tanzhenbio.com |
| Products Intro: |
Product Name:Ac-QPKK(Ac)-AMC
CAS:1387005-23-3
Purity:98% HPLC Package:10mg;100mg;1000mg
|
| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
| Products Intro: |
Product Name:Ac-QPKK(Ac)-AMC
CAS:1387005-23-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Ac-QPKK(Ac)-AMC
CAS:1387005-23-3
Purity:98% Package:1mg;5mg;10mg
|
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| | Ac-QPKK(Ac)-AMC Basic information |
| Product Name: | Ac-QPKK(Ac)-AMC | | Synonyms: | Ac-QPKK(Ac)-AMC;LDN-05233;L-Lysinamide, N2-acetyl-L-glutaminyl-L-prolyl-L-lysyl-N6-acetyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-;N2-acetyl-L-glutaminyl-L-prolyl-L-lysyl-N6-acetyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide | | CAS: | 1387005-23-3 | | MF: | C36H52N8O9 | | MW: | 740.85 | | EINECS: | | | Product Categories: | | | Mol File: | 1387005-23-3.mol |  |
| | Ac-QPKK(Ac)-AMC Chemical Properties |
| Boiling point | 1217.4±65.0 °C(Predicted) | | density | 1.281±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble,Ethanol: soluble | | form | A solid | | pka | 12.52±0.20(Predicted) | | Sequence | Ac-Gln-Pro-Lys-{Lys(Ac)}-AMC |
| | Ac-QPKK(Ac)-AMC Usage And Synthesis |
| Uses | Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin through sirtuin deacetylation[1]. | | Biological Activity | Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin 1 (SIRT1), SIRT2, and SIRT3.1 It is selectively deacylated by SIRT1-3 over SIRT6. Upon enzymatic cleavage by SIRT1, SIRT2, or SIRT3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify SIRT1, SIRT2, and SIRT3 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. | | References | 1.Galleano, I., Schiedel, M., Jung, M., et al.A continuous, fluorogenic sirtuin 2 deacylase assay: Substrate screening and inhibitor evaluationJ. Med. Chem.59(3)1021-1031(2017) |
| | Ac-QPKK(Ac)-AMC Preparation Products And Raw materials |
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