| Company Name: |
ChemeGen 中国
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:3-Oxobetulin Acetate
CAS:136587-07-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:3-Oxobetulin Acetate
CAS:136587-07-0
Purity:95% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.com |
| Products Intro: |
Product Name:3-Oxobetulin Acetate
CAS:136587-07-0
Purity:详情请点击官网 Package:1 mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:3-Oxobetulin Acetate
CAS:136587-07-0
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| | 3-Oxobetulin Acetate Basic information |
| | 3-Oxobetulin Acetate Chemical Properties |
| Melting point | 77-79 °C | | Boiling point | 532.7±23.0 °C(Predicted) | | density | 1.019±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 25 mg/ml | | form | A crystalline solid |
| | 3-Oxobetulin Acetate Usage And Synthesis |
| Biological Activity | 3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin .1 It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 μg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 μg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 μg/ml for both).2 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50 = 13.4 μM).3 It is also active against L. donovani amastigotes when used at a concentration of 50 μM.1 | | References | 1.Alakurtti, S., Bergstr?m, P., Sacerdoti-Sierra, N., et al.Anti-leishmanial activity of betulin derivativesJ. Antibiot. (Tokyo)63(3)123-126(2010)
2.Pettit, G.R., Melody, N., Hempenstall, F., et al.Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimerJ. Nat. Prod.77(4)863-872(2014)
3.Callies, O., Bedoya, L.M., Beltrán, M., et al.Isolation, structural modification, and HIV inhibition of pentacyclic lupane-type triterpenoids from Cassine xylocarpa and Maytenus cuzcoinaJ. Nat. Prod.78(5)1045-1055(2015) |
| | 3-Oxobetulin Acetate Preparation Products And Raw materials |
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