| Company Name: |
Dalian Meilun Biotech Co., Ltd.
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| Tel: |
0411-62910999 13889544652 |
| Email: |
sales@meilune.com |
| Products Intro: |
Product Name:3-TDA
CAS:116296-31-2
Purity:>98%,BR Package:2MG Remarks:MB6155
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:3-Thiatetradecanoic acid
CAS:116296-31-2
Purity:98% Package:1G;10G;100G Remarks:3-Thiatetradecanoic acid (3-thia TDA) is an analog of the 14-carbon saturated fatty acid myristic acid, wherein the C-3 carbon has been replaced by sulfur in a thioether linkage.
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:(UNDECYLTHIO)-ACETIC ACID
CAS:116296-31-2
Purity:98% Package:10mg; 5mg Remarks:Medbio
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| | (UNDECYLTHIO)-ACETIC ACID Basic information |
| | (UNDECYLTHIO)-ACETIC ACID Chemical Properties |
| Melting point | 61-62 °C | | Boiling point | 359.0±25.0 °C(Predicted) | | density | 0.978±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 3.85±0.10(Predicted) |
| | (UNDECYLTHIO)-ACETIC ACID Usage And Synthesis |
| Biological Activity | 3-thiatetradecanoic acid is an activator of ppar.the peroxisome proliferator-activated receptors (ppars) are transcription factors involved in fatty acid metabolism and energy homeostasis. the ppars also play crucial roles in the control of cellular growth and differentiation. | | in vitro | in bt4cn cells, 3-thiatetradecanoic acid could activate all ppar subtypes dose-dependently. in cell culture experiments, the pparγ-selective ligand brl49653 moderately inhibited growth of bt4cn cells, while administration of 3-thiatetradecanoic acid led to a marked growth inhibition. moreover, the administration of the pparγ-selective antagonist gw9662 abolished brl49653-induced growth inhibition, but only marginally reduced the effect of 3-thiatetradecanoic acid [1]. | | in vivo | administration of 3-thiatetradecanoic acid increased mitochondrial and peroxisomal beta-oxidative capacity and carnitine palmitoyltransferase activity, but reduced free fatty acid and triacylglycerol levels in plasma compared to palmitic acid-treated rats and controls. 3-thiatetradecanoic acid administration was able to affect the fatty acid composition in plasma and liver by increasing the amount of monoenes [2]. | | references | 1. berge k, tronstad kj, flindt en, rasmussen th, madsen l, kristiansen k, berge rk. tetradecylthioacetic acid inhibits growth of rat glioma cells ex vivo and in vivo via ppar-dependent and ppar-independent pathways. carcinogenesis. 2001 nov;22(11):1747-55.2. asiedu, d.k.,froyland, l.,vaagenes, h., et al. long-term effect of tetradecylthioacetic acid: a study on plasma lipid profile and fatty acid composition and oxidation in different rat organs. biochimica et biophysica acta 1300, 86-96 (1996).3. pettersen rj, salem m, skorve j, ulvik rj, berge rk, nordrehaug je. pharmacology and safety of tetradecylthioacetic acid (tta): phase-1 study. j cardiovasc pharmacol. 2008 apr;51(4):410-7. |
| | (UNDECYLTHIO)-ACETIC ACID Preparation Products And Raw materials |
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