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| | Ambucaine Basic information |
| Product Name: | Ambucaine | | Synonyms: | Ambucaine;Ambucain;Ambutoxate;S-813;Sympocain;WIN-3706;2-diethylaminoethyl 4-amino-2-butoxybenzoate;2-diethylaminoethyl 4-azanyl-2-butoxy-benzoate | | CAS: | 119-29-9 | | MF: | C17H28N2O3 | | MW: | 308.419 | | EINECS: | | | Product Categories: | | | Mol File: | 119-29-9.mol |  |
| | Ambucaine Chemical Properties |
| | Ambucaine Usage And Synthesis |
| Originator | Ambucaine,ZYF Pharm Chemical | | Manufacturing Process | A stired mixture of 4-nitro-2-hydroxybenzoic acid, anhydrous potassium
carbonate and n-butyl benzenesulfonate in xylene was refluxed under a
continuous water separator for about 19 h. The insoluble potassium salts were
filtered off and washed with hot dry toluene. The combined filtrate and
washings were distilled under reduced pressure to remove the solvents,
thereby leaving a residual oil which solidified on cooling. The solid yields of
greater than 95% of n-butyl 4-nitro-2-n-butoxybenzoate (recrystallized from
methanol).
The n-butyl 4-nitro-2-n-butoxybenzoate obtained was dissolved in 50%
aqueous ethanol. To this solution was added 2 - 3 molecular equivalents of
sodium carbonate, and the resulting mixture, was stirred under reflux for
about 16 h. After the ethanol has been distilled off under reduced pressure,
the remaining aqueous solution was diluted with water and made acidic with
concentrated hydrochloric acid. The precipitated yellow solid was filtered,
washed with water, dried in a vacuum oven at 90°C and recrystallized from
ethyl acetate. There was thus obtained a 4-nitro-2-n-butoxy-benzoic acid
(95.5% yield), melting point 120.9°-122.8°C (corr.).
A mixture of 4-nitro-2-n-butoxybenzoic acid, anhydrous potassium carbonate
and 400 ml of dry toluene was refluxed and stirred under a continuous water
separator. When the evolution of water had ceased (3 h), the water separator
was removed and there was added diethylaminoethyl chloride. The mixture
was then refluxed with stirring for about 20 h, filtered while hot, and the
solvent was removed from the filtrate by distilling in vacuo. The residual oil
was dissolved in dilute hydrochloric acid, the solution was decolorized with
activated carbon and the base was liberated by the addition of excess
ammonia. The base was extracted with ethyl acetate, the solution was dried,
and the ethyl acetate was removed by distilling in vacuo, yielding 2-
diethylaminoethyl 4-nitro-2-n-butoxybenzoate as a pale yellow oil.
The 2-diethylaminoethyl 4-nitro-2-n-butoxybenzoate in ethanol is
hydrogenated using 50 lbs. pressure of hydrogen at 25°C in the presence of
Raney nickel (alternatively platinum oxide monohydrate). After the rapid
exothermic reaction, the catalyst is filtered off and the filtrate evaporated to
dryness to give the 2-diethylaminoethyl 4-amino-2-n-butoxybenzoate. | | Therapeutic Function | Local anesthetic |
| | Ambucaine Preparation Products And Raw materials |
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