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| 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Basic information |
Product Name: | 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine | Synonyms: | 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE;1H-Pyrazolo[3,4-d]pyrimidine,4,6-dichloro-;4,6-dichloropyrrolo[2,3-d]pyrimidine;4,6-Dichloro-1H-pyrazole[3,4-D]pyriMidine;4,6-Dichloropyrazolo[3,4-d]pyriMidine;6-Dichloro-1H-pyrazolo[3;4,6-dichloro-1H-pyrazolo[3,4-d]pP03119ine;4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE(RS20012005) | CAS: | 42754-96-1 | MF: | C5H2Cl2N4 | MW: | 189 | EINECS: | 948-193-9 | Product Categories: | Aromatics;Heterocycles;Building Blocks;Pyrazolo[x,x-y]pyridine;Heterocycle-Pyrimidine series;CHIRAL CHEMICALS | Mol File: | 42754-96-1.mol | |
| 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties |
Melting point | 145 °C (decomp) | Boiling point | 251.9±50.0 °C(Predicted) | density | 2.02±0.1 g/cm3(Predicted) | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | solubility | DMSO (Slightly), Methanol (Slightly) | form | solid | pka | 7.90±0.20(Predicted) | color | Off-white to yellow |
Hazard Codes | T | Risk Statements | 25 | Safety Statements | 45-24/25 | RIDADR | UN2811 | HazardClass | IRRITANT | HS Code | 29335990 |
| 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Usage And Synthesis |
Chemical Properties | Yellow solid | Synthesis | To a solution of 2,4,6-trichloropyrimidine-5-carbaldehyde (19.0 g, 990 mmol) in methanol (300 mL) was added drop-wise a solution of hydrazine monohydrate (4.8 mL) in methanol (80 mL) at 0 °C followed by drop-wise addition of triethylamine (13 mL) in methanol (80 mL) at 0 °C. The mixture was stirred at the same temperature for 30 mm. The solvent was removed, and the residue was purified by flash chromatography to afford 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine (10.3 g, 62 % yield) as a yellow solid. ‘H NMR (CDC13, 400IVIHz): 11.56 (br, 1H), 8.43 (s, 1H). MS m/z 190.68 [M+1].
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| 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials |
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