- Doxorubicinone
-
- $2200.00 / 1g
-
2024-02-02
- CAS:24385-10-2
- Min. Order: 1g
- Purity: 98
- Supply Ability: 5 Kg
|
| | Doxorubicinone Basic information |
| Product Name: | Doxorubicinone | | Synonyms: | Epirubicin aglycon;5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-;Ccris 7633;8-glycoloyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-5,12-Naphthacenedione;Doxorubicin aglycone;Doxorubicinone;Epirubicin aglycone;5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)- | | CAS: | 24385-10-2 | | MF: | C21H18O9 | | MW: | 414.36 | | EINECS: | | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Metabolites & Impurities;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 24385-10-2.mol |  |
| | Doxorubicinone Chemical Properties |
| Melting point | 223-225°C | | Boiling point | 741.2±60.0 °C(Predicted) | | density | 1.671±0.06 g/cm3(Predicted) | | storage temp. | Amber Vial, -20°C Freezer | | solubility | Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 7.45±0.60(Predicted) | | color | Red to Very Dark Red | | Stability: | Light Sensitive | | InChI | InChI=1S/C21H18O9/c1-30-11-4-2-3-8-14(11)20(28)16-15(17(8)25)18(26)9-5-21(29,12(24)7-22)6-10(23)13(9)19(16)27/h2-4,10,22-23,26-27,29H,5-7H2,1H3/t10-,21-/m0/s1 | | InChIKey | IBZGBXXTIGCACK-CWKPULSASA-N | | SMILES | C1(OC)=C2C(C(=O)C3=C(C2=O)C(O)=C2C(C[C@@](O)(C(CO)=O)C[C@@H]2O)=C3O)=CC=C1 | | CAS DataBase Reference | 24385-10-2 |
| | Doxorubicinone Usage And Synthesis |
| Description | Doxorubicinone is a metabolite of the anthracycline antitumor antibiotic doxorubicin . Doxorubicinone inhibits mitochondrial succinoxidase from bovine heart and reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria in a concentration-dependent manner. Doxorubicinone (40 μM) increases pentose phosphate pathway flux by 45% and reduces activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) by 17 and 60%, respectively, in human erythrocytes. It also induces cytotoxicity in patient-derived ovarian cancer colonies in a concentration-dependent manner. | | Chemical Properties | Red Solid | | Uses | A metabolite of Doxorubicin (Dx). | | Definition | ChEBI: Adriamycinone is a member of tetracenes and a quinone. | | General Description | Doxorubicinone (adriamycinone) is an aglycone. It is a metabolite of adriamycin converted in the body, and another metabolite is amycinol [1]. Adriamycin nephropathy (AN) is a rodent model of chronic kidney disease. AN is characterized by podocyte injury followed by glomerulosclerosis, tubulointerstitial inflammation and fibrosis. | | References | [1] Emara S, et al. Effect of cyclodextrins on the stability of adriamycin,
adriamycinol, adriamycinone and daunomycin. Talanta, 2008; 51: 359-364. |
| | Doxorubicinone Preparation Products And Raw materials |
|