1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-(2-chloroacetyl)-4-(2-furanylmethyl)- manufacturers
- ZL-Pin01
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- $1520.00
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2026-04-21
- CAS:1047464-92-5
- Purity:
- Supply Ability: 10g
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| | 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-(2-chloroacetyl)-4-(2-furanylmethyl)- Basic information |
| | 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-(2-chloroacetyl)-4-(2-furanylmethyl)- Chemical Properties |
| Boiling point | 581.2±50.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | pka | -0.57±0.20(Predicted) |
| | 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-(2-chloroacetyl)-4-(2-furanylmethyl)- Usage And Synthesis |
| Uses | ZL-Pin01 is a high potent covalent Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) inhibitor. ZL-Pin01 shows potent disruption of the Pin1-substrate interaction with an IC50 of 1.33 μM[1]. | | References | [1] Liu L, et al. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J Med Chem. 2022;65(3):2174-2190. DOI:10.1021/acs.jmedchem.1c01686 |
| | 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-(2-chloroacetyl)-4-(2-furanylmethyl)- Preparation Products And Raw materials |
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