| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:c-Met-IN-14
CAS:2443380-34-3
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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Propanimidamide, N-[[(4-chlorophenyl)methyl]sulfonyl]-N'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-3-methoxy- manufacturers
- c-Met-IN-14
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- $1520.00 / 25mg
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2025-07-30
- CAS:2443380-34-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Propanimidamide, N-[[(4-chlorophenyl)methyl]sulfonyl]-N'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-3-methoxy- Basic information |
| | Propanimidamide, N-[[(4-chlorophenyl)methyl]sulfonyl]-N'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-3-methoxy- Chemical Properties |
| Boiling point | 804.9±75.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | pka | 2.32±0.40(Predicted) |
| | Propanimidamide, N-[[(4-chlorophenyl)methyl]sulfonyl]-N'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-3-methoxy- Usage And Synthesis |
| Uses | c-Met-IN-14 (compound 26af) is a selective inhibitor of c-Met kinase from N-sulfonylamidine-based derivatives, with an IC50 value of 2.89 nM. c-Met-IN-14 shows anticancer activity by blocking phosphorylation of c-Met, and arrests cell cycle at G2/M phase. c-Met-IN-14 induces apoptosis of A549 cells in a dose-dependent manner[1]. | | in vivo | c-Met-IN-14 (compound 26af) (p.o.; 8 mg/kg) exhibits safety profile and favorable pharmacokinetic properties in BALB/c mouse, with rapid absorption (Tmax=2.5 h), high maximum concentration (Cmax=1228.4 ng/mL), high plasma exposure (AUC0-∞=6.8 μg.h.mL-1), accepted elimination half-life (T1/2=3.5 h), and well clearance (1.18 L.h-1.kg-1), has a moderate oral bioavailability (74%) in mouse[1].
c-Met-IN-14 (i.p.; below 200 mg/kg) doesn’t cause abnormalities, anaphylactic responses, allergic reactions on mice[1].
| Animal Model: | 8-week-old male BALB/c mice [1] | | Dosage: | 0 (vehicle), 100, 200, 300, or 400 mg/kg | | Administration: | Intraperitoneal injection; treatment on day 0 and assessment every 3 days for 15 days | | Result: | Showed no obvious toxicity in acute toxicity tests. |
| Animal Model: | Pharmacokinetic profiles of compound 26af in BALB/c mouse[1]
| | Dosage: | | | Administration: | | | Result: | | Route | Dose (mg/kg) | T1/2 (h) | Cmax (ng.mL-1) | Tmax (h) | AUC0-∞ (μg.h.mL-1) | CL (L.h-1.kg-1) | CL (%) | | i.v. | 2 | 1.8 | 675.6 | - | 2.3 | - | | | p.o. | 8 | 3.5 | 1228.4 | 2.5 | 6.8 | 1.18 | 74 |
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| | References | [1] Nan X, et al. Design, synthesis and biological evaluation of novel N-sulfonylamidine-based derivatives as c-Met inhibitors via Cu-catalyzed three-component reaction. Eur J Med Chem. 2020 Aug 15. 200:112470. DOI:10.1016/j.ejmech.2020.112470 |
| | Propanimidamide, N-[[(4-chlorophenyl)methyl]sulfonyl]-N'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-3-methoxy- Preparation Products And Raw materials |
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